Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Trim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes

ABSTRACT: Trim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes

PROVIDER: PRJNA471853 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7178170_1.fastq.gz	Fastqsanger.gz
	SRR7178170_2.fastq.gz	Fastqsanger.gz
	SRR7178171_1.fastq.gz	Fastqsanger.gz
	SRR7178171_2.fastq.gz	Fastqsanger.gz
	SRR7178172_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Trim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes

Project description:RNAseq were performed to analyze the transcriptomic differences between Trim27-overexpressing MP and empty vector control MP

2018-06-01 | GSE114579 | GEO

Autophagy driven by a master regulator of hematopoiesis

Project description:Developmental and homeostatic remodeling of cellular organelles is mediated by a complex process termed autophagy. The cohort of proteins that constitute the autophagy machinery function in a multistep biochemical pathway. Though components of the autophagy machinery are broadly expressed, autophagy can occur in specialized cellular contexts, and mechanisms underlying cell type-specific autophagy are poorly understood. We demonstrate that the master regulator of hematopoiesis GATA-1 directly activates transcription of genes encoding the essential autophagy component Microtubule Associated Protein 1 Light Chain 3B (LC3B) and its homologs (MAP1LC3A, GABARAP, GABARAPL1, GATE-16). In addition, GATA-1 directly activates genes involved in the biogenesis/function of lysosomes, which mediate autophagic protein turnover. We demonstrate that GATA-1 utilizes the forkhead protein FoxO3 to activate select autophagy genes. GATA-1-dependent LC3B induction is tightly coupled to accumulation of the active form of LC3B and autophagosomes, which mediate mitochondrial clearance as a critical step in erythropoiesis. These results illustrate a novel mechanism by which a master regulator of development establishes a genetic network to instigate cell type-specific autophagy. Genome-wide maps of GATA1 factor occupancy in primary human PBMC derived erythroblasts

2011-09-30 | E-GEOD-32491 | biostudies-arrayexpress

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia

Project description:MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia

| PRJNA1207514 | ENA

Calcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.

Project description:Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here we report a novel role for calcineurin/NFAT signaling as a negative regulator of myeloid hematopoiesis. Reconstituting lethally-irradiated mice with hematopoietic stem cells expressing an NFAT-inhibitory peptide resulted in enhanced development of the myeloid compartment. Culturing bone marrow cells with Flt3-L and Cyclosporin A, which inhibits NFAT signaling, increased numbers of differentiated DC. Global gene expression analysis of untreated DC and NFAT-inhibited DC revealed differential expression of transcripts that regulate cell cycle and apoptosis. Thus, calcineurin/NFAT signaling negatively regulates myeloid lineage development. The finding that NFAT acts as a negative regulator of myeloid development provides novel insight in understanding immune responses during treatment with calcineurin/NFAT inhibitors as Cyclosporin A. bone marrow cells from C57B/6 mice were stimulated in Flt3-L suplemented media in presence or absence of calcineurin/NFAT inhibitor Cyclosporin A, samples in 3 biological replicates

2011-09-30 | E-GEOD-29094 | biostudies-arrayexpress

Autophagy driven by a master regulator of hematopoiesis

2011-09-30 | GSE32491 | GEO

Dysregulated RPB1 is a targetable master driver of overgrowth in acute myeloid leukemia.

Project description:Dysregulated RPB1 is a targetable master driver of overgrowth in acute myeloid leukemia.

| PRJNA518881 | ENA

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [ATAC-seq]

Project description:MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [ATAC-seq]

| PRJNA1206112 | ENA

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [SLAM-seq]

Project description:MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [SLAM-seq]

| PRJNA1206119 | ENA