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Kinome profiling of Non-Hodgkin’s lymphoma reveals Tyro3 is important in primary effusion lymphoma survival

ABSTRACT: Kinome profiling of Non-Hodgkin’s lymphoma reveals Tyro3 is important in primary effusion lymphoma survival

PROVIDER: PRJNA472630 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7207180.fastq.gz	Fastqsanger.gz
	SRR7207190.fastq.gz	Fastqsanger.gz
	SRR7207171.fastq.gz	Fastqsanger.gz
	SRR7207181.fastq.gz	Fastqsanger.gz
	SRR7207191.fastq.gz	Fastqsanger.gz

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Kinome profiling of Non-Hodgkin’s lymphoma reveals Tyro3 is important in primary effusion lymphoma survival

Project description:Non-Hodgkin’s lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated and important for cell survival in primary effusion lymphoma (PEL). We developed an inhibitor against Tyro3 named UNC3810A, which inhibited cell growth in PEL but not in other NHL subtypes. UNC3810A also significantly inhibited tumor progression in a PEL xenograft mouse model compared to the vehicle treated animals. Our data suggests Tyro3 may be a therapeutic target for PEL.

2019-07-10 | GSE114791 | GEO

Kinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL

Project description:Non-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).

2019-07-11 | PXD012087 | Pride

Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma.

Project description:Non-Hodgkin lymphomas (NHLs) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely up-regulated in different NHL subtypes. Using multiplexed inhibitor bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely up-regulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi's sarcoma-associated herpesvirus (KSHV). Tyro3 was also highly expressed in PEL cell lines as well as in primary PEL exudates. Based on this discovery, we developed an inhibitor against Tyro3 named UNC3810A, which hindered cell growth in PEL, but not in other NHL subtypes where Tyro3 was not highly expressed. UNC3810A also significantly inhibited tumor progression in a PEL xenograft mouse model that was not seen in a non-PEL NHL model. Taken together, our data suggest Tyro3 is a therapeutic target for PEL.

| S-EPMC6697815 | biostudies-literature

Primary effusion lymphoma cell lines BC-1 and BC-3

Project description:Microarray analysis of primary effusion lymphoma cell lines BC-1 and BC-3

2011-11-16 | GSE31745 | GEO

Expression in Primary Effusion Lymphoma (PEL) BCBL-1 compared to BJAB (BL cell line) and L-428 (cHD cell line)

Project description:Infection of B lymphocytes by HHV-8 is associated with the development of Primary Effusion Lymphoma (PEL). By microarray we identify differential expressions in three pro-inflammatory factors; LTA4H, TSP-1 and IL-16 in the BCBL-1 in comparison to BJAB (BL cell line) By microarray we identify differential expressions in three pro-inflammatory factors; LTA4H, TSP-1 and IL-16 in the BCBL-1 in comparison to L-428 a Classical Hodgkin’s disease cell line (cHD) as compared to BJAB a BL cell line. Keywords: Direct cell to cell comparison

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Evaluation of a Low Density DNA Microarray for Small B-Cell non-Hodgkin’s Lymphoma Differential Diagnosis

Project description:Lymphomas are classified according to the World Health Organization (WHO) classification which defines subtypes on the basis of clinical, morphological, immunophenotypic, molecular and cytogenetic criteria. Using this model, 8 of 9 of the validation samples were classified successfully. This pilot study demonstrates that such a microarray tool may be a promising diagnostic approach for small B-cell non-Hodgkin’s lymphoma. Keywords: Small B-Cell non-Hodgkin’s Lymphoma, Low Density DNA Microarray, Diagnosis

2009-03-25 | GSE11635 | GEO

Classical Hodgkin’s Lymphoma: Molecular evidence for specific alterations of circulating T lymphocytes

Project description:Gene expression profiles were performed from CD3+ T cells isolated from peripheral blood samples of untreated patients with cHL versus 2 control groups consisting of healthy donors and patients with sarcoidosis. Keywords = Hodgkin’s Lymphoma Keywords = T cell Keywords = immune regulation Keywords: repeat sample

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Affymetrix 500K SNP array data for Primary Effusion Lymphoma samples

Project description:Affymetrix 500K array was used to determine gross genomic aberrations in a panel of Primary Effusion Lymphoma (PEL) cell lines, specifically focusing on chromosome 10, which includes the Phosphatase and Tensin Homolog (PTEN) locus.

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microRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP

Project description:This SuperSeries is composed of the following subset Series: GSE31745: Primary effusion lymphoma cell lines BC-1 and BC-3 GSE31746: BJAB Cell Lines Transduced with lentiviral vector pNL-SIN-CMV-AcGFP expressing KSHV miRNAs miR-K1, miR-K12-11, or miR-K4-3p GSE32109: microRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina] Refer to individual Series

2011-11-16 | E-GEOD-32113 | biostudies-arrayexpress

3D genome landscapes of primary effusion lymphoma cell lines link super-enhancers to dependency factors

Project description:H3K27ac HiChIP and ChIP-seq to identify super enhancers inprimary effusion lymphoma cell lines (PEL)

2020-10-06 | GSE136090 | GEO