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Expression data from Knockdown of ILF3 in DLD1 cell line

ABSTRACT: Expression data from Knockdown of ILF3 in DLD1 cell line

PROVIDER: PRJNA474101 | ENA |

REPOSITORIES: ENA

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Expression data from Knockdown of ILF3 in DLD1 cell line

Project description:Colorectal cancer malignant progression depends on the aberrant oncogenic expressions. During tumorigenesis, the oncogeneic genes mutation or expression, following specific sets of genes are up-regulated or down-regulated. Some of them, for instance, control metabolism reprogramming to promote tumor growth and maliganant progression. We used microarrays to detail the global programme of gene expression regulated by ILF3, which is overexpressed in colorectal cancer.

2019-08-08 | GSE115200 | GEO

Expression data from Knockdown of BAF53A in DLD1 cell line

Project description:Expression data from Knockdown of BAF53A in DLD1 cell line

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Knockdown of ILF2/ILF3 (NF45/NF90) in the gastric cancer cell line SGC7901

Project description:Our data showed that lncRNA ELF3-AS1 could bind on the exon1 of ELF3-201 to form a double-stranded RNA molecule. This double-stranded RNA could interact with ILF2/ILF3 complex. To explore the biofunction of the interaction between ELF3-AS1 and ILF2/ILF3 complex, loss-of-function studies regarding ILF2 and ILF3 were performed in SGC7901 cell line. RNA sequencing studies showed that knockdown of ILF3 significantly decreased ELF3-AS1, while knockdown of ILF2 significantly increased ELF3-AS1 and NF90 expression. Our data revealed that ILF2/ILF3 complex interacted with ELF3-AS1/ELF3 double-stranded RNA and regulated their transcripts stability.

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Expression data from DLD1 cells following H19 knockdown

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Knockdown of ILF2/ILF3 (NF45/NF90) in the gastric cancer cell line SGC7901

Project description:Knockdown of ILF2/ILF3 (NF45/NF90) in the gastric cancer cell line SGC7901

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DLD1

Project description:DLD1 is an APC mut, KRAS mut, P53 mut CRC cell line. PROX1 transcription factor, target of Wnt pathway in CRC, is our protein of interest.DLD1 cells are PROX1 negative. We overexpressed through lentiviral expression PROX1 protein or the empty vector psd44, through selection of the cells in puromycin resistance. Afterwards we compared the transcriptional program of the DLD1-PROX1 and DLD1-Control cells growing in monolayer in vitro.

2014-09-18 | E-MTAB-2020 | biostudies-arrayexpress

shRNA Knockdown of ILF3 in Monocyte-Derived Dendritic Cells (MDDCs)

Project description:Antigen presenting cells such as myeloid dendritic cells (DCs) are key sentinels of the innate immune system. In response to pathogen recognition and innate immune stimulation, DCs transition from an immature, inactive state to a mature, active state that is characterized by widespread changes in host gene expression. Several key transcription factors are known to drive these gene expression changes, but the mechanisms that negatively regulate DC maturation are less well understood. Here, we have identified that the transcription factor Interleukin Enhancer Binding Factor 3 (ILF3) is a negative regulator of innate immune responses and DC maturation. Depletion of ILF3 in primary human monocyte-derived DCs (MDDCs) using shRNA knockdown led to increased expression of maturation markers and potentiated innate responses at baseline.

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Expression data from YAP-S127D DLD1 Xenografts

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Gene expression changes upon Lamin A and Lamin B2 depletion in a diploid colorectal cancer cell line - DLD1

Project description:Small interfering RNA (siRNA) mediated depletion of Lamin A/C and Lamin B2 was performed in a diploid colorectal cancer cell line - DLD1 with an aim to identify transcription deregulation across the genome.

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RIP-seq using ILF3 antibodies to reveal RNAs that binds to ILF3 protein

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