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C. elegans DLC-1 is a component of diverse ribonucleoprotein complexes

ABSTRACT: C. elegans DLC-1 is a component of diverse ribonucleoprotein complexes

PROVIDER: PRJNA474476 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7254040.fastq.gz	Fastqsanger.gz
	SRR7254050.fastq.gz	Fastqsanger.gz
	SRR7254041.fastq.gz	Fastqsanger.gz
	SRR7254051.fastq.gz	Fastqsanger.gz
	SRR7254032.fastq.gz	Fastqsanger.gz

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C. elegans DLC-1 is a component of diverse ribonucleoprotein complexes

Project description:Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here we use a genomic approach to identify transcripts associated with DLC-1, a protein previously identified as a cofactor of two unrelated RNA-binding proteins that act in the C. elegans germline. Among the 2732 potential DLC-1 targets, most are germline mRNAs. Removal of DLC-1 affects expression of its targets, meg-1 and meg-3. We propose that DLC-1 acts as a cofactor for multiple ribonucleoprotein complexes, thus making diverse contributions to RNA regulation in the germline.

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