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Genetic signatures of retinal ganglion cells revealed through single cell profiling [dissociated RGC]

ABSTRACT: Genetic signatures of retinal ganglion cells revealed through single cell profiling [dissociated RGC]

PROVIDER: PRJNA474543 | ENA |

REPOSITORIES: ENA

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Genetic signatures of retinal ganglion cells revealed through single cell profiling [non-dissociated RGC]

Project description:This study aimed to characterize the transcriptomes of adult retinal ganglion cells (RGCs). The physiological properties of these cells were characterized first in non-dissociated retinal tissue. With that information recorded, the cells were isolated for transcriptome profiling.

2019-11-01 | GSE115379 | GEO

Genetic signatures of retinal ganglion cells revealed through single cell profiling [non-dissociated RGC]

Project description:Genetic signatures of retinal ganglion cells revealed through single cell profiling [non-dissociated RGC]

| PRJNA474735 | ENA

Genetic signatures of retinal ganglion cells revealed through single cell profiling [dissociated RGC]

Project description:This study aimed to characterize the transcriptomes of adult retinal ganglion cells (RGCs). These cells were isolated through their expression of a TdTomato molecule that would only turn on when Cre was present. Cre was controlled by the Parvalbumin promoter.

2019-11-01 | GSE115332 | GEO

Transcription profiling of chicken whole eye and retinal ganglion cells (RGC) to identify RGC-specific genes

Project description:Identification of genes regulated by ATH5 in a dose-dependent manner.; Identification of retinal ganglion cells (RGC)-specific genes.

2009-01-14 | E-TABM-417 | biostudies-arrayexpress

Subcellular expression profiling of the growth cones of retinal ganglion cells (RGC)

Project description:Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used to isolate the growth cones of retinal ganglion cell (RGC) axons of two vertebrate species, mouse and Xenopus, coupled with unbiased genome-wide microarray profiling. Localized mRNA from the isolated growth cones of Xenopus laevis and Mus musculus retinal ganglion cells were subjected to microarray analysis

2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress

Subcellular expression profiling of the growth cones of retinal ganglion cells (RGC)

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Shtn1, a retinal ganglion cell (RGC) specific gene, regulates RGC neurite development: Insights from an RGC direct somatic cell reprogramming model

Project description:Retinal ganglion cells (RGCs) are the projection neurons of the retina. Proper development of the axon and dendrite of RGCs is the basis for these cells to function as projection neurons to deliver visual information to the brain. The purpose of this study was to investigate the function of a newly identified RGC-specific gene, Shtn1, in neurite development in RGCs. Using IF, we demonstrated that SHTN1 is distinctively expressed in RGCs during the period in which RGCs actively develop and adjust the connections of their neurites with upstream and downstream neurons. Using the iRGC system, we demonstrated that Shtn1 promotes the growth and complexity of neurites, and thus the electrophysiological maturation, of iRGCs. RNA-Seq analyses showed that Shtn1 may also regulate gene expression and neurogenesis in iRGCs. These findings improve our understanding of the molecular machinery governing RGC neurite development, and may help to optimize future RGC regeneration methods.

2024-07-10 | GSE254839 | GEO

Shtn1, a retinal ganglion cell (RGC) specific gene, regulates RGC neurite development: Insights from an RGC direct somatic cell reprogramming model

Project description:Shtn1, a retinal ganglion cell (RGC) specific gene, regulates RGC neurite development: Insights from an RGC direct somatic cell reprogramming model

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Enriched retinal ganglion cells derived from human embryonic stem cells (RNA-seq)

Project description:We performed the whole transcriptome analysis in human H9 ES cells and in retinal ganglion cells (RGC) derived from H9 ES cells.

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Subcellular expression profiling of the growth cones of retinal ganglion cells (RGC)

Project description:Subcellular expression profiling of the growth cones of retinal ganglion cells (RGC)

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