Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Expression data from control and CTIP2-/- (BCL11B) hESC-derived medium spiny neurons

PROVIDER: PRJNA474679 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7299380_1.fastq.gz	Fastqsanger.gz
	SRR7299380_2.fastq.gz	Fastqsanger.gz
	SRR7299381_1.fastq.gz	Fastqsanger.gz
	SRR7299381_2.fastq.gz	Fastqsanger.gz
	SRR7299382_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Homo sapiens

Project description:Expression data from control and BCL11B-/- hESC-derived striatal medium spiny neurons and cortical glutamatergic neurons

| PRJNA767962 | ENA

Single-cell RNA-seq of hESC (H9) lines exposed to a striatal differentiation protocol

Project description:Use of single-cell transcriptomics to measure how well medium spiny projection neurons, derived from human ESC, recapitulate human striatal development in vivo. This in vitro single-cell dataset was derived after exposing hESC lines (H9) to a novel striatal differentiation protocol and performing single-cell RNA-seq after 15 days and 25 days of differentiation.

2023-01-31 | E-MTAB-12080 | biostudies-arrayexpress

Postnatal Conditional Knockout of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease

Project description:Dysregulation of the striatum is linked to multiple diseases including Huntington’s (HD), Parkinson’s, X-linked dystonia-parkinsonism (XDP), addiction, autism, and schizophrenia. Striatal medium spiny neurons (MSNs) make up 90% of the neuronal cell type in the striatum and are critical to motor control. The transcription factor Bcl11b (also known as CTIP2) is known to regulate of MSN differentiation, striatal striosome (patch) development and the architecture of the striatum during development. However, the function of Bcl11b adult striatal neurons in vivo has not been investigated. Therefore, we conditionally knocked out Bcl11b specifically in MSNs using D9-cre under the control of a regulatory elements of the mouse Ppp1r1b gene encoding DARPP-32 resulting in knockout around 5-6 weeks of age. Transcriptomic and behavioral analysis were performed on these mice.

2022-11-02 | GSE185476 | GEO

Mus musculus

Project description:Comparative analysis of Drd1+ Medium Spiny Neurons and Drd2+ Medium Spiny Neurons

| PRJNA113951 | ENA

Mus musculus

Project description:Comparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, Motor Neurons, and Purkinje Neurons

| PRJNA113957 | ENA

Mus musculus

Project description:Comparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, cocaine treatment

| PRJNA113955 | ENA

Mus musculus

Project description:Comparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons and whole brain

| PRJNA113953 | ENA

Expression data from of HD-iPSC and CON-iPSC neuron derivatives

2015-09-02 | GSE59051 | GEO

Expression data from of HD-iPSC and CON-iPSC neuron derivatives

Project description:Compared the global gene expression profiles of HD- and CON-iPSC-derived neurons We used microarrays to detail the global programme of gene expression for comparing the global gene expression profiles of HD- and CON-iPSC-derived neurons and facilitating studies of medium spiny neurons (MSN)-degenerative processes of Huntington's Disease (HD). By using a step-wise in vitro differentiation protocol combining EB formation, neural induction by small molecules, treatment with inhibitors of the TGFß pathway (SB431542) and the BMP pathway (LDN193189), and mechanical isolation/purification of neural progenitors and neurons, we induced 60-70% of control iPSCs or HD-iPSCs to differentiate into GABA- and DARPP-32- double positive neurons.

2015-09-02 | E-GEOD-59051 | biostudies-arrayexpress

Cell specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age related motor impairment

Project description:Microarray data of RNA collected from wild type and PGC-1α null medium spiny neurons prior to apperance of vacuoles to understand affects on transcriptome.

2017-06-27 | GSE100510 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data