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Differential Expression of LncRNAs of cisplatin-resistant versus parental CAL-27 cells

ABSTRACT: Differential Expression of LncRNAs of cisplatin-resistant versus parental CAL-27 cells

PROVIDER: PRJNA474743 | ENA |

REPOSITORIES: ENA

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Differential Expression of LncRNAs of cisplatin-resistant versus parental CAL-27 cells

Project description:Chemoresistance frequently leads to therapeutic failure in tongue squamous cell carcinoma (TSCC). Increasing evidence has shown that Long noncoding RNAs (lncRNAs) play pivotal roles in biological properties of cancer. However, the roles and mechanisms of lncRNAs in cisplatin resistance are not well understood. In this study, to identify the lncRNAs induced by chemotherapy, we profile the expression of lncRNAs in cisplatin-resistant TSCC cells using LncRNA microarrays.

2018-06-12 | GSE115119 | GEO

Analysis of miRNA sublocalization in cisplatin-resistant versus parental CAL-27 cells

Project description:Analysis of miRNA sublocalization in cisplatin-resistant versus parental CAL-27 cells

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Differential Expression of LncRNAs after cisplatin treatment in tongue squamous carcinoma cells

Project description:chemoresistance frequently leads to therapeutic failure in oral squamous cell carcinoma (OSCC). Recently, studies have reported that lncRNAs play active roles in regulation biological properties of cancer. To understand whether lncRNAs involve in regulating cisplatin sensitivity in TSCC, in this study, we profiled the expression of lncRNAs in two TSCC cell lines(CAL-27 and SCC-9) under cisplatin treatment paired untreated cell lines by LncRNA Array (ArrayStar V3.0).

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Analysis of miRNA sublocalization in cisplatin-resistant versus parental CAL-27 cells

Project description:Chemoresistance frequently leads to therapeutic failure in oral squamous cell carcinoma (OSCC). While miRNA have been widely reported having global regulatory roles in cancer biological properties, yet their localiztion alteration under cisplatin treatment has not been clarified. In this study, to identify the sublocalization characteristics of miRNAs induced by chemotherapy, especially the specific mitochondrial localization of miRNA, we profile the expression of miRNAs in cisplatin-resistant and parental TSCC cells using miRNA microarrays.

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Differential Expression of miRNAs in control and NR_034085-silenced OSCCs under cisplatin treatment

Project description:chemoresistance frequently leads to therapeutic failure in oral squamous cell carcinoma (OSCC). Recently, studies have reported that lncRNAs play active roles in regulation biological properties of cancer and may regulate the expression of miRNA. We also found that miRNAs could regulate cisplatin sensitivity in TSCC previously. In this study, to explore the potential targets of lncRNAs in response to cisplatin, we performed microarray to detect miRNAs both in control and NR_034085–silenced CAL-27 and SCC-9 cells under cisplatin treatment.

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Gene expression profile in tongue squamous carcinoma cells with stably transduced with LINC01011 shRNA under cisplatin treatment

Project description:chemoresistance frequently leads to therapeutic failure in oral squamous cell carcinoma (OSCC). Recently, studies have reported that lncRNAs play active regulatory roles in gene transcription and further regulate biological properties of cancer in this way. In this study, to further expore lncRNAs downstream target gene in regulating mitochondrial fission and cisplatin sensitivity in TSCC, we profiled the expression of gene in two TSCC cell lines(CAL-27 and SCC-9) after LINC01011 knockdown and treated with cisplatin treatment for 24h.

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RNA-Seq analysis LEF1 or KDM4A knockdown effect on CAL-27 cells

Project description:To investigate the carcinogenesis function LEF1 or KDM4A in the regulation of oral squamous cell carcinoma, we used siRNA knockdown of LEF1 or KDM4A in CAL-27 cells.

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Expression data from Empty control, PMM1 wildtype and R150H mutation clones in Cal-27 cells

Project description:To exmaine the PMM1-relative tumor suppression transcriptome in OSCC cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with empty vector, PMM1-wildtype and R150H mutation in Cal-27 cells

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Development of gene expression signatures of CAL-27 cells for treatment of shXBP-1s.

Project description:We have employed mRNA microarray expression profiling as a discovery platform to identify genes with the potential to explain how knockdown of XBP-1s upregulated the cell membrane expression of HLA of CAL-27 cells. Both knockdown group and control group were comfirmed to be stable transfected.

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Expression data from AKR1C1 over-expression in Cal-27 cells or knockdown in HSC-2 cells, respectively

Project description:To exmaine the AKR1C1 controls transcriptome in HNSCC cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with empty vector or AKR1C1 expression vector in Cal-27 cells and shLuc control or shAKR1C1 in HSC-2 cells

2019-12-18 | GSE119444 | GEO

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