Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular Basis of Hereditary Retinal Degenerations

ABSTRACT: Molecular Basis of Hereditary Retinal Degenerations

PROVIDER: PRJNA475319 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Molecular Basis of Hereditary Retinal Degenerations

Project description:Molecular Basis of Hereditary Retinal Degenerations

| PRJNA475318 | ENA

Molecular basis of retinal remodeling in a Zebrafish model of Retinitis Pigmentosa

Project description:A hallmark of inherited retinal degenerative diseases such as Retinitis Pigmentosa (RP) is progressive structural and functional remodeling of the remaining retinal cells as photoreceptors degenerate. Extensive remodeling of the retina stands as a barrier for the successful implementation of strategies to restore vision. To understand the molecular basis of remodeling, we performed analyses of single-cell transcriptome data from adult Zebrafish retina of wild-type and a P23H mutant rhodopsin transgenic model of RP with continuous degeneration and regeneration. We provide a benchmark atlas of retinal cell type transcriptomes in Zebrafish and find changes in all retinal cell types in the P23H model. These include widespread oxidative stress, changes in reliance on oxidative metabolism and glycolysis, widespread synaptic remodeling, and changes in circadian rhythm regulation. This comprehensive transcriptomic analysis provides a molecular road map to understand how the retina remodels in the context of chronic retinal degeneration with ongoing regeneration.

2023-11-10 | GSE234435 | GEO

Molecular basis of retinal remodeling in a Zebrafish model of Retinitis Pigmentosa

Project description:Molecular basis of retinal remodeling in a Zebrafish model of Retinitis Pigmentosa

| PRJNA981359 | ENA

Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes

Project description:Objectives: 1. To examine the variations in clinical features, survival outcomes, family history, and health behavior among proband patients who are known or suspected to have a hereditary colorectal cancer syndrome 2. To compare the clinical features, survival outcomes, and health behavior of the proband vs. his/her family members who may or may not be affected by the hereditary colorectal cancer syndrome 3. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in the overall disease phenotype across probands and kindreds, within a given syndrome. Disease phenotype is defined to include: (1) clinicopathologic features including patient demographics and oncologic outcomes; (2) clinical manifestations of disease including the timing, spectrum and severity of CRC and extracolonic cancers. Genetic variations may include the specific codon mutated, the type of mutation and sequence alteration (e.g. nonsense, missense etc), chromosomal/gene copy number changes, and gene polymorphisms. 4. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in somatic CRC tumor biology, including tumor pathology and other tumor molecular markers

| 2222117 | ecrin-mdr-crc

Molecular basis of Urostyle development

Project description:Molecular basis of Urostyle development

| PRJNA1017454 | ENA

Molecular basis of beige adipocyte maintenance

Project description:Molecular basis of beige adipocyte maintenance

| PRJEB11461 | ENA

Molecular Basis of Neuroendocrine Prostate Cancer

Project description:Molecular Basis of Neuroendocrine Prostate Cancer

| PRJNA282856 | ENA

Molecular basis of TPE-OLD [methylation]

Project description:Molecular basis of TPE-OLD [methylation]