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Similarities and differences in the regulation of HoxD genes during chick and mouse limb development.

ABSTRACT: Similarities and differences in the regulation of HoxD genes during chick and mouse limb development.

PROVIDER: PRJNA475482 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7288050.fastq.gz	Fastqsanger.gz
	SRR7288060.fastq.gz	Fastqsanger.gz
	SRR7288070.fastq.gz	Fastqsanger.gz
	SRR7288080.fastq.gz	Fastqsanger.gz
	SRR7288090.fastq.gz	Fastqsanger.gz

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Project description:Similarities and differences in the regulation of HoxD genes during chick and mouse limb development [ChIP-Seq]

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Project description:Hoxd genes are important for limb development in all tetrapods examined thus far. In mouse, they are controlled by a complex bimodal regulation, which regulates first the proximal patterning, then the distal structure, allowing at the same time the formation of the wrist and ankle articulations. We analyzed the existence of this regulatory mechanism in chicken, i.e. in an animal where large morphological differences exist between fore- and hindlimbs. We report that while this bimodal regulation is globally conserved between mammals and avian, some important modifications evolved at least between these two model systems, in particular regarding the activity of specific enhancer and the position of the TAD boundary and the forelimb versus hindlimb comparative regulations. Some aspects of these regulations seem to be more conserved between chick and bats than with the mouse situation, which may relate to the extent to which forelimbs and hindlimbs of these various animals differ in their functions.

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Project description:In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then the distal structure. During the shift from the former to the latter regulation, this bimodal regulatory mechanism allows the production of a domain with low Hoxd gene expression, at which both telomeric (T-DOM) and centromeric regulatory domains (C-DOM) are silent. These cells generate the future wrist and ankle articulations. We analyzed the implementation of this regulatory mechanism in chicken, i.e., in an animal for which large morphological differences exist between fore- and hindlimbs. We report that although this bimodal regulation is globally conserved between the mouse and the chick, some important modifications evolved at least between these two model systems, in particular regarding the activity of specific enhancers, the width of the TAD boundary separating the two regulations, and the comparison between the forelimb versus hindlimb regulatory controls. At least one aspect of these regulations seems to be more conserved between chick and bats than with mouse, which may relate to the extent to which forelimbs and hindlimbs of these various animals differ in their morphologies.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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