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Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

ABSTRACT: Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

PROVIDER: PRJNA476962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7405152.fastq.gz	Fastqsanger.gz
	SRR7405153.fastq.gz	Fastqsanger.gz
	SRR7405154.fastq.gz	Fastqsanger.gz

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Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

Project description:We conducted a network-based analysis of the Aft2 transcription factor involved in iron starvation response in Candida glabrata.

2018-12-11 | GSE116077 | GEO

Candida glabrata WT and mutants under iron starvation

Project description:Transcriptional time series of Candida glabrata under iron starvation (SD medium without Fe). Wild type and deletion mutants of the iron-related transcription factors Aft1 and Sef1, as well as of the iron uptake transporter Ftr1 as a positive control.

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Comparative Transcriptomics Highlights New Features of the Iron Starvation Response in the Human Pathogen Candida glabrata.

Project description:In this work, we used comparative transcriptomics to identify regulatory outliers (ROs) in the human pathogen Candida glabrata. ROs are genes that have very different expression patterns compared to their orthologs in other species. From comparative transcriptome analyses of the response of eight yeast species to toxic doses of selenite, a pleiotropic stress inducer, we identified 38 ROs in C. glabrata. Using transcriptome analyses of C. glabrata response to five different stresses, we pointed out five ROs which were more particularly responsive to iron starvation, a process which is very important for C. glabrata virulence. Global chromatin Immunoprecipitation and gene profiling analyses showed that four of these genes are actually new targets of the iron starvation responsive Aft2 transcription factor in C. glabrata. Two of them (HBS1 and DOM34b) are required for C. glabrata optimal growth in iron limited conditions. In S. cerevisiae, the orthologs of these two genes are involved in ribosome rescue by the NO GO decay (NGD) pathway. Hence, our results suggest a specific contribution of NGD co-factors to the C. glabrata adaptation to iron starvation.

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Transcriptome analyses of the response of C. glabrata wild type cells to iron excess, salt excess, cadmium treatment and iron starvation

Project description:A Candida glabrata wild type strain (HTL, as described in Schwartzmuller et al., PLoS Pathog. 2014 Jun 19;10(6):e1004211) was submitted to various stress conditions (iron excess, salt excess, cadmium treatment and iron starvation (BPS treatment). The cells were collected 20 and 40 minutes after the beginning of treatments and their transcriptomes were compared to those of mock treated cells.

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Candida glabrata transcription profile when grown under Niacin starvation or in human urine

Project description:The transcription profile of Candida glabrata grown under two different Niacin limitation conditions were determined. Condition 1 is comparing log phase C. glabrata cells (O.D. 0.5-0.6) grown in synthetic medium containing 0.016 uM versus 3.25 uM nicotinic acid (NA), a common form of Niacin. The NA concentration of 3.25 uM is the standard concentration in synthetic complete (SC) medium. Condition 2 is comparing log phase C. glabrata cells (O.D. 0.4-0.6) grown in 3 individual human urine samples (supplemented with 2% glucose) versus in SC medium. Keywords: transcriptional profiling by microarray

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Response of Candida glabrata to environmental iron availability

Project description:To examine the response of Candida glabrata cells to iron-depleted and iron-repleted environmental conditions, transcriptional profiling analysis was carried out on wild-type and Cghog1∆ cells grown either in presence of BPS or ferric chloride. Genes involved in iron transport and homeostasis, oxidative phosphorylation, amino acid metabolic process and chromatin silencing were found to be differentially regulated.

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Project description:Microarray experiments were performed to reveal the key genes involved in iron homeostasis in the pathogenic yeast Candida glabrata.

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The CCAAT-Binding Complex Controls Mitochondrial Activity and Iron Homeostasis in Candida glabrata

Project description:We conducted a network-based analysis of the Hap5 transcription factor belonging to the CCAAT-Binding Complex in Candida glabrata.

2017-04-30 | GSE91371 | GEO

A network of paralogous stress response transcription factors in the human pathogen Candida glabrata

Project description:We conducted a network-based analysis of the seven transcription factors belonging to the Yap (Yeast AP1) family in Candida glabrata.

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Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway [Cgla RNA-seq]

Project description:In S. cerevisiae, the phosphate starvation (PHO) responsive transcription factors Pho4 and Pho2 are jointly required for induction of phosphate response genes and survival in phosphate starvation conditions. In the related human commensal and pathogen C. glabrata, Pho4 is required but Pho2 is dispensable for survival in phosphate-limited conditions and is only partially required for inducing the phosphate response genes. This reduced dependence on Pho2 evolved in C. glabrata and closely related species. Pho4 orthologs that are less dependent on Pho2 induce more genes when introduced into the S. cerevisiae background, and Pho4 in C. glabrata both binds to more sites and induces more genes with expanded functional roles compared to Pho4 in S. cerevisiae. We used RNA-seq to profile the transcriptome of wild type and mutants of Pho4 / Pho2 in C. glabrata, to identify genes induced by Pho4.

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