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Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

ABSTRACT: Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

PROVIDER: PRJNA476962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7405152.fastq.gz	Fastqsanger.gz
	SRR7405153.fastq.gz	Fastqsanger.gz
	SRR7405154.fastq.gz	Fastqsanger.gz

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Comparative transcriptomics highlights new features of the iron starvation response in the human pathogen Candida glabrata

Project description:We conducted a network-based analysis of the Aft2 transcription factor involved in iron starvation response in Candida glabrata.

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Comparative Transcriptomics Highlights New Features of the Iron Starvation Response in the Human Pathogen <i>Candida glabrata</i>.

Project description:In this work, we used comparative transcriptomics to identify regulatory outliers (ROs) in the human pathogen Candida glabrata. ROs are genes that have very different expression patterns compared to their orthologs in other species. From comparative transcriptome analyses of the response of eight yeast species to toxic doses of selenite, a pleiotropic stress inducer, we identified 38 ROs in C. glabrata. Using transcriptome analyses of C. glabrata response to five different stresses, we pointed out five ROs which were more particularly responsive to iron starvation, a process which is very important for C. glabrata virulence. Global chromatin Immunoprecipitation and gene profiling analyses showed that four of these genes are actually new targets of the iron starvation responsive Aft2 transcription factor in C. glabrata. Two of them (HBS1 and DOM34b) are required for C. glabrata optimal growth in iron limited conditions. In S. cerevisiae, the orthologs of these two genes are involved in ribosome rescue by the NO GO decay (NGD) pathway. Hence, our results suggest a specific contribution of NGD co-factors to the C. glabrata adaptation to iron starvation.

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Transcriptome analyses of the response of C. glabrata wild type cells to iron excess, salt excess, cadmium treatment and iron starvation

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Candida glabrata transcription profile when grown under Niacin starvation or in human urine

Project description:The transcription profile of Candida glabrata grown under two different Niacin limitation conditions were determined. Condition 1 is comparing log phase C. glabrata cells (O.D. 0.5-0.6) grown in synthetic medium containing 0.016 uM versus 3.25 uM nicotinic acid (NA), a common form of Niacin. The NA concentration of 3.25 uM is the standard concentration in synthetic complete (SC) medium. Condition 2 is comparing log phase C. glabrata cells (O.D. 0.4-0.6) grown in 3 individual human urine samples (supplemented with 2% glucose) versus in SC medium. Keywords: transcriptional profiling by microarray

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