Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Microbiome in Severe Combined Immunodeficiency (X-linked)

PROVIDER: PRJNA477357 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7408000_1.fastq.gz	Fastqsanger.gz
	SRR7408000_2.fastq.gz	Fastqsanger.gz
	SRR7408010_1.fastq.gz	Fastqsanger.gz
	SRR7408010_2.fastq.gz	Fastqsanger.gz
	SRR7408020_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 278

Similar Datasets

Project description:Preclinical Development of a Lentiviral Vector for Gene Therapy of X-linked Severe Combined Immunodeficiency

| PRJNA438481 | ENA

Project description:Severe Immunodeficiency

| PRJNA397356 | ENA

Project description:A de novo mutation in ITPR3 causes severe combined immunodeficiency

| PRJNA913788 | ENA

A de novo mutation in ITPR3 causes severe combined immunodeficiency

Project description:A de novo mutation in ITPR3 causes severe combined immunodeficiency

| PRJEB58049 | ENA

Project description:Severe combined immunodeficiency with ligase 1 deficiency and Omenn-like manifestation

| PRJEB56316 | ENA

Homo sapiens

Project description:Bcl11b defect in a human severe combined immunodeficiency with multisystem anomalies

| PRJNA335768 | ENA

Homo sapiens

Project description:Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9 Enhanced Gene Replaceme

| PRJNA278158 | ENA

Homo sapiens

Project description:Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9 Enhanced Gene Replaceme

| PRJNA278160 | ENA

Inherited BCL10 deficiency with impaired hematopoietic and non-hematopoietic immunity

Project description:Whole exome sequencing (WES) files of a patient suffering from a combined immunodeficiency, and his parents.

2014-10-31 | E-MTAB-2962 | biostudies-arrayexpress

Gene expression profile of the IL2RG gene depletion in pig spleen

Project description:Severe combined immunodeficiency (SCID) occurs in various species, including humans, at a frequency as high as one per 50,000 live births. Generally, SCID can be classified according to the cause of the immunodeficiency, and it includes impaired cytokine-mediated signalling, defective V(D)J recombination, impaired pre-T-cell receptor signalling, and metabolic enzyme deficiencies. Although mice with disrupted SCID-causing genes have provided important insights into the human disease, not all the SCID mice have phenotypes that resemble those in human SCID patients. In humans, most SCID patients are reported to have impaired cytokine-mediated signalling in immune cells. IL2RG is a key component of the immune system, which is associated with the development of X-linked SCID in humans. Despite some phenotypic characterisations and functional studies being performed in SCID animals, little is known about the molecular basis of the different phenotypes of SCID in mouse and pig. In the present experiment, we generated monoallelic IL2RG (mIL2RG+/Δ69-368) KO pigs and investigated patterns of gene expression during their immune development in order to further explore our understanding of immune responses in X-linked SCID.

2016-09-27 | GSE77579 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data