Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Canine hip dysplasia

PROVIDER: PRJNA477464 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7411530_1.fastq.gz	Fastqsanger.gz
	SRR7411530_2.fastq.gz	Fastqsanger.gz
	SRR7411540_1.fastq.gz	Fastqsanger.gz
	SRR7411540_2.fastq.gz	Fastqsanger.gz
	SRR7411550_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 96

Similar Datasets

Project description:Genomic variants associating with canine hip dysplasia

| PRJEB41117 | ENA

Project description:Genetic polymorphisms of different chromosomal regions in dogs with Canine Hip Dysplasia

| PRJEB24783 | ENA

Gene Expression in Hip Soft Tissues in a Natural Canine Model of Developmental Dysplasia of the Hip

Project description:Gene Expression in Hip Soft Tissues in a Natural Canine Model of Developmental Dysplasia of the Hip

| PRJNA449364 | ENA

Genomic variants associating with canine hip dysplasia

Project description:Validation study of SNPs associating with canine hip dysplasia

2020-11-05 | PRJEB41117 | EVA

Canis lupus familiaris cultivar:Canis lupus familiaris

Project description:Hip dysplasia gene correction using PE

| PRJNA855566 | ENA

Effects of aging on Human Mesenchymal Stem Cells

Project description:In the present study we analyzed the effect of advanced donor age on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from bone marrow. Human MSC of elderly and middle-aged patients without symptoms of osteoporosis were isolated from femoral heads after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Bone marrow was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. RNA samples were taken from passage 1 or passage 2.

2012-02-22 | E-GEOD-35955 | biostudies-arrayexpress

Periostin induces early articular cartilage degeneration in developmental dysplasia of the hip

Project description:Developmental dysplasia of the hip (DDH) is one of the significant risk factors for hip osteoarthritis. In order to investigate the factors that induce early articular cartilage degeneration of the hip joints that are exposed to reduced dynamic loads arising from hip dislocation , we created rodent models of hip dislocation by swaddling. Notably, expression of periostin (Postn) was increased in the acetabular articular cartilage of the DDH models; Postn was a candidate gene associated with early articular cartilage degeneration. We showed that early articular cartilage degeneration was suppressed in Postn-/- DDH mice. Furthermore, a microgravity environment induced the expression of Postn in chondrocytes through STAT3 signaling. Postn induced catabolic factors, interleukin-6 and matrix metalloproteinase 3, in articular chondrocytes through integrin-nuclear factor κB signaling. Additionally, interleukin-6 stimulated Postn expression through STAT3 signaling. Thus, Postn plays a critical role in early articular cartilage degeneration associated with hip dislocation.

2022-07-20 | GSE173637 | GEO

Effects of Cellular Senescence on Human Mesenchymal Stem Cells

Project description:In the present study we analyzed the effect of cellular senescence on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from bone marrow. Human MSC were isolated from femoral heads of non-osteoporotic donors after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Bone marrow was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. MSC were replated after reaching 70-90% confluence until they entered state of cellular senescence. RNA samples of control cells were taken from passage 1 or passage 2.

2012-02-22 | E-GEOD-35957 | biostudies-arrayexpress

Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip

Project description:Aims: Developmental dysplasia of the hip (DDH) is a complex musculoskeletal disease that occurs mostly in children. This study aimed to investigate the molecular changes in the hip joint capsule of patients with DDH. Results: More than one thousand genes were differentially expressed in hip joint capsules between healthy controls and DDH. Both gene ontology (GO) and Kyoto encyclopedia of genes and genome (KEGG) analyses revealed that extracellular matrix (ECM) modifications, muscle system processes, and cell proliferation were markedly influenced by the differentially expressed genes. Conclusion: DDH is associated with the loss of collagen fibers and fibroblasts, which may cause loose joint capsule formation. However, the degree of differentiation of fibroblasts to myofibroblasts needs further studies.

2022-03-21 | GSE169494 | GEO

Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip

Project description:Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip

| PRJNA716732 | ENA