Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD) Genomes

ABSTRACT: Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD) Genomes

PROVIDER: PRJNA477898 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD) Genomes

Project description:Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD) Genomes

| PRJNA477899 | ENA

Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD): Global Microbiome Conservancy Host Exomes

Project description:Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD): Global Microbiome Conservancy Host Exomes

| PRJNA671406 | ENA

Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD): Global Microbiome Conservancy Host Exomes

Project description:Center for Common Disease Genomics [CCDG] - Inflammatory Bowel Disease (IBD): Global Microbiome Conservancy Host Exomes

| PRJNA671405 | ENA

Label free-DDA nano-LC/MS/MS analysis of Human Mesenteric lymph collected from Inflammatory Bowel Disease (IBD) subjects.

Project description:Compromise of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. The intestinal epithelial cells form a barrier of selective permeability which protects from invasion by the normal bacteria present in the gut. When the barrier is compromised, bacteria and their products can attack the cells and cause inflammation, which can (in severe cases) cause sepsis. Mesenteric lymph nodes play a crucial role in the immune response and are of particular importance in the study of Inflammatory Bowel Disease (IBD) patients due to their involvement in the disease process. To assess the efficiency of gut immune barrier, we collected the pre-nodal lymph from Inflammatory Bowel Disease (IBD) subjects and performed a comprehensive proteomic analysis. The current study is complementary extension of the proteomics signature found in DSS-induced colitis mouse model, providing an insight in the lymph composition, and associated biochemical changes, in the set of samples (n=6) recruited from the Inflammatory Bowel Disease (IBD), subjects undergoing intestinal resection. Following bottom-up analysis, the enrichment analysis – GO and Ingenuity pathway analysis (IPA) analysis identified several pathways pointing towards a damaging phenotype.

2024-08-09 | PXD044801 | Pride

Whole blood expression profiling of patients with inflammatory bowel diseases in IBD-Character cohort

Project description:The IBD-Character cohort (Edinburgh, Oslo, Örebro, Linköping, Zaragoza, Maastricht) included patients with inflammatory bowel diseases (IBD: Crohn's disease, ulcerative colitis) recruited at diagnosis and non-IBD controls. Paired-end RNA sequencing was used for whole blood expression profiling. Raw and normalized counts tables are provided.

2022-03-01 | E-MTAB-11349 | biostudies-arrayexpress

Center for Common Disease Genomics [CCDG] - Cardiovascular: TexGen

Project description:Center for Common Disease Genomics [CCDG] - Cardiovascular: TexGen

| PRJNA865439 | ENA

Center for Common Disease Genomics [CCDG] - Cardiovascular: TexGen

Project description:Center for Common Disease Genomics [CCDG] - Cardiovascular: TexGen

| PRJNA865440 | ENA

Center for Common Disease Genomics [CCDG] - Cardiovascular: TAICHI

Project description:Center for Common Disease Genomics [CCDG] - Cardiovascular: TAICHI

| PRJNA419021 | ENA

Center for Common Disease Genomics [CCDG] - Cardiovascular: TAICHI

Project description:Center for Common Disease Genomics [CCDG] - Cardiovascular: TAICHI

| PRJNA419022 | ENA

nano-LC/MS/MS analysis of Human Mesenteric lymph endogenous peptidome isolated from Inflammatory Bowel Disease (IBD) subjects.

Project description:A compromised pathology of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. When the epithelial barrier is compromised, bacteria and their products can attack the cells and cause inflammation, sometime leading to sepsis. Studying the lymph peptidome in inflammatory bowel disease (IBD) can offer valuable insights into the underlying mechanisms, disease progression, and potential therapeutic targets. To assess the efficiency of gut immune barrier, we collected the pre-nodal lymph from Inflammatory Bowel Disease (IBD) subjects and performed a comprehensive peptidomic analysis. . The current study is complementary extension of the proteomics signature found in DSS-induced colitis mouse model, providing an insight in the lymph composition inclined to an inflammatory phenotype which was also mirrored by a unique set of peptidome/degradome. Furthermore, the identified peptides mapped to a wide range of intracellular and extracellular pathways, encompassing cellular stress, apoptosis, and extracellular matrix degradation related pathways. A significant fraction of peptides was also found to be derived from bacterial origin with a predicted binding affinity to different MHC I and MHC II human haplotypes.

2024-08-10 | PXD051024 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data