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Metabolic switch explains the sublethal effects induced by glyphosate-based herbicide in tadpoles of a farmland frog Microhyla fissipes

ABSTRACT: Metabolic switch explains the sublethal effects induced by glyphosate-based herbicide in tadpoles of a farmland frog Microhyla fissipes

PROVIDER: PRJNA478033 | ENA |

REPOSITORIES: ENA

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Metabolic switch explains the sublethal effects induced by glyphosate-based herbicide in tadpoles of a farmland frog Microhyla fissipes

Project description:The sublethal effects of a practically nontoxic GBH (KISSUN®) were investigated in tadpoles of M. fissipes, a farmland inhabiting amphibian. GBH exposure caused higher temperature preference, growth suppression, shorter and weaker tails in these tadpoles. These sublethal effects would likely affect the environmental adaptation ability, locomotor activity, competitive capacity and survival rate of tadpoles and thus might have profound influence on their population dynamics. Higher temperature preference might be an adaptive strategy for improving the efficiency of damage repair system activated by GBH exposure, as well as compensating for the reduced locomotor activity and sustaining energy metabolism. Growth suppression and tail morphological change were associated with reduced intensity of overall protein synthesis and structural protein synthesis, especially muscle specific genes. Transcriptional analysis suggested that GBH-treated tadpoles had suppressed carbohydrate and lipid catabolism, while encouraged amino acid catabolism. We speculated that metabolic switch to amino acid might be an adaptive strategy for compensating the reduced contribution of carbohydrate and lipid in energy production, and it provide a metabolic explanation for the downregulation of protein synthesis, growth synthesis and morphological change. Our results systemically revealed the molecular processes underlying the sublethal effects in an amphibian caused by GBH. It suggested that metabolic switch might be a consensus toxicologic mechanism of growth suppression across fish and amphibians.

2021-06-26 | GSE116301 | GEO

Microhyla fissipes

Project description:Microhyla fissipes overview

| PRJNA328049 | ENA

Microhyla fissipes

Project description:Microhyla fissipes Raw sequence reads

| PRJNA831372 | ENA

Microhyla fissipes

Project description:Microhyla fissipes Raw sequence reads

| PRJNA382881 | ENA

Microhyla fissipes

Project description:Microhyla fissipes Raw sequence reads