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Epigenetic and transcriptomic profiling of mammary gland development and tumor models disclose regulators of cell state plasticity

ABSTRACT: Epigenetic and transcriptomic profiling of mammary gland development and tumor models disclose regulators of cell state plasticity

PROVIDER: PRJNA478444 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7448170_1.fastq.gz	Fastqsanger.gz
	SRR7448170_2.fastq.gz	Fastqsanger.gz
	SRR7448180_1.fastq.gz	Fastqsanger.gz
	SRR7448180_2.fastq.gz	Fastqsanger.gz
	SRR7448190.fastq.gz	Fastqsanger.gz

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Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Project description:Cell state reprogramming during tumor progression complicates accurate diagnosis, compromises therapeutic effectiveness, and fuels metastatic dissemination. We used chromatin accessibility assays and transcriptional profiling during mammary development as an agnostic approach to identify factors that mediate cancer cell state interconversions. We show that fetal and adult basal cells share epigenetic features consistent with multi-lineage differentiation potential. We find that DNA-binding motifs for SOX transcription factors are enriched in chromatin that is accessible in stem/progenitor cells and inaccessible in differentiated cells. In both mouse and human tumors, SOX10 expression correlates with stem/progenitor identity, dedifferentiation, and invasive characteristics. Strikingly, we demonstrate that SOX10 binds to genes that regulate neural crest cell identity, and that SOX10-positive tumor cells exhibit neural crest cell features.

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Epigenetic and transcriptomic profiling of mammary gland development and tumor models disclose regulators of cell state plasticity

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-29 | GSE116386 | GEO