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Mutation analysis of parental and 10 avirulent C. rodentium isolates from the feces of C3H/HeJ mice

ABSTRACT: Mutation analysis of parental and 10 avirulent C. rodentium isolates from the feces of C3H/HeJ mice

PROVIDER: PRJNA479471 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7468340_1.fastq.gz	Fastqsanger.gz
	SRR7468340_2.fastq.gz	Fastqsanger.gz
	SRR7468341_1.fastq.gz	Fastqsanger.gz
	SRR7468341_2.fastq.gz	Fastqsanger.gz
	SRR7468332_1.fastq.gz	Fastqsanger.gz

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Mutation analysis of parental and 10 avirulent C. rodentium isolates from the feces of C3H/HeJ mice

Project description:We report that dietary iron protects mice from infection by Citrobacter rodentium. Iron induces a state of insulin resistance and increases glucose availability in the gut, thereby attenutating C. rodentium virulence. Additionally the pathogen appears to be driven towards a long-term commensal state. Here, we identify mutations in persistent and avirulent Citrobacter rodentium isolates from mice given an iron supplemented diet.

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