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NOTCH3-IC

ABSTRACT: NOTCH3-IC

PROVIDER: PRJNA480489 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8924406.fastq.gz	Fastqsanger.gz
	SRR8924407.fastq.gz	Fastqsanger.gz
	SRR8924408.fastq.gz	Fastqsanger.gz
	SRR8924409.fastq.gz	Fastqsanger.gz

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Reversible induction NOTCH3-IC in SH-SY5Y.

Project description:Expression analysis of ADRN cell line SH-SY5Y with transient- or permanent doxycycline-inducible NOTCH3-IC expression was used to study reversibility of transcriptional reprogramming.

2019-04-04 | GSE116891 | GEO

Time-course inducible NOTCH3-IC expression in SH-SY5Y.

Project description:Expression analysis of ADRN cell line SH-SY5Y with doxycycline-inducible NOTCH3-IC was used to study transcriptional reprogramming to a MES state.

2019-04-04 | GSE116890 | GEO

Xenograft SH-SY5Y tumors with inducible NOTCH3-IC expression.

Project description:Expression analysis of xenograft tumors of ADRN cell line SH-SY5Y with doxycycline-inducible NOTCH3-IC was used to study transcriptional reprogramming to a MES state in vivo.

2019-04-04 | GSE116892 | GEO

Reversible induction NOTCH3-IC in SH-SY5Y.

Project description:Reversible induction NOTCH3-IC in SH-SY5Y.

| PRJNA480494 | ENA

Xenograft SH-SY5Y tumors with inducible NOTCH3-IC expression.

Project description:Xenograft SH-SY5Y tumors with inducible NOTCH3-IC expression.

| PRJNA480496 | ENA

Time-course inducible NOTCH3-IC expression in SH-SY5Y.

Project description:Time-course inducible NOTCH3-IC expression in SH-SY5Y.

| PRJNA480495 | ENA

AKT dependent Notch3 activation drives tumor progression in a model of mesenchymal colorectal cancer subtype

Project description:Recently a consensus molecular subtype (CMS) classification of colorectal cancer (CRC) has been established that is based on the transcriptional rather than the genetic profile of an individual tumor and which may ultimately help to individualize CRC therapy. So far, however, the lack of appropriate animal models that faithfully recapitulate the different molecular subtypes impedes adequate preclinical testing of stratified therapeutic concepts. Here we demonstrate that constitutive AKT activation in intestinal epithelial cells markedly enhances colonic tumor invasion and metastasis in Trp53DIEC mice (Trp53ΔIECAktE17K) upon challenge with the carcinogen azoxymethane (AOM). Gene-expression profiling indicates that Trp53ΔIECAktE17K tumors closely resemble the human mesenchymal colorectal cancer subtype (CMS4), which is characterized by the poorest survival rate among the four consensus molecular subtypes of CRC. Trp53ΔIECAktE17K tumors are further characterized by a NOTCH pathway gene signature and a distinct cell autonomous upregulation of Notch3 in tumor epithelia while treatment of Trp53ΔIECAktE17K mice with a NOTCH3-inhibiting antibody reduces invasion and metastasis. Conversely, selective activation of NOTCH3 by overexpression of NOTCH3-IC in Akt wt tumor organoids strongly promotes development of metastasis in an orthotopic transplantation model. In CRC patients NOTCH3 expression correlates positively with tumor grading and the presence of lymph node as well as distant metastases and is specifically upregulated in CMS4 tumors. Therefore, we suggest NOTCH3 as a putative target for advanced CMS4 CRC patients.

2021-09-08 | PXD014778 | Pride

NOTCH3-IC

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-04 | GSE116893 | GEO

Notch3 ChIP-sequencing of brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation

Project description:Molecular mechanisms underlying the differentiation of brain mural cells from neural crest are poorly understood. We found that activation of Notch3 signaling in human pluripotent stem cell-derived neural crest (using lentiviral overexpression of the human Notch3 intracellular domain, N3ICD) was sufficient to direct the differentiation of mural cells. We used Notch3 ChIP-sequencing to identify cis-regulatory elements directly bound by the Notch3 transcriptional activation complex in this system.

2024-02-02 | GSE205212 | GEO

AKT dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer subtype [2015]

2020-07-29 | GSE136254 | GEO