Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (development RNA-Seq)

ABSTRACT: Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (development RNA-Seq)

PROVIDER: PRJNA480866 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7515900.fastq.gz	Fastqsanger.gz
	SRR7515910.fastq.gz	Fastqsanger.gz
	SRR7515920.fastq.gz	Fastqsanger.gz
	SRR7515901.fastq.gz	Fastqsanger.gz
	SRR7515911.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (Fn14 KO RNA-Seq)

Project description:Sensory experience influences the establishment of neural connectivity through molecular mechanisms that remain unclear. Here, we employ single-nucleus RNA-sequencing to investigate the contribution of sensory-driven gene expression to synaptic refinement in the dorsal lateral geniculate nucleus of the thalamus, a region of the brain that processes visual information. We find that visual experience induces the expression of the cytokine receptor Fn14 in excitatory thalamocortical neurons. By combining electrophysiological and structural techniques, we show that Fn14 is dispensable for early phases of refinement mediated by spontaneous activity, but that Fn14 is essential for refinement during a later, experience-dependent period of development. Refinement deficits in mice lacking Fn14 are associated with functionally weaker and structurally smaller retinogeniculate inputs, indicating that Fn14 mediates both functional and anatomical rearrangements in response to sensory experience. These findings identify Fn14 as a molecular link between sensory-driven gene expression and vision-sensitive refinement in the brain.

2021-07-12 | GSE117023 | GEO

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (development RNA-Seq)

2021-07-12 | GSE117022 | GEO

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus RNA-Seq)

2021-07-12 | GSE117021 | GEO

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus single nucleus RNA-Seq)

2021-07-12 | GSE117020 | GEO

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement

Project description:Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement

| PRJNA480863 | ENA

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (Fn14 KO RNA-Seq)

Project description:Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (Fn14 KO RNA-Seq)

| PRJNA480868 | ENA

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus RNA-Seq)

Project description:Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus RNA-Seq)

| PRJNA480867 | ENA

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus single nucleus RNA-Seq)

Project description:Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement (stimulus single nucleus RNA-Seq)

| PRJNA480865 | ENA

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement.

Project description:Sensory experience influences the establishment of neural connectivity through molecular mechanisms that remain unclear. Here, we employ single-nucleus RNA sequencing to investigate the contribution of sensory-driven gene expression to synaptic refinement in the dorsal lateral geniculate nucleus of the thalamus, a region of the brain that processes visual information. We find that visual experience induces the expression of the cytokine receptor Fn14 in excitatory thalamocortical neurons. By combining electrophysiological and structural techniques, we show that Fn14 is dispensable for early phases of refinement mediated by spontaneous activity but that Fn14 is essential for refinement during a later, experience-dependent period of development. Refinement deficits in mice lacking Fn14 are associated with functionally weaker and structurally smaller retinogeniculate inputs, indicating that Fn14 mediates both functional and anatomical rearrangements in response to sensory experience. These findings identify Fn14 as a molecular link between sensory-driven gene expression and vision-sensitive refinement in the brain.

| S-EPMC6101651 | biostudies-literature

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-12 | GSE117024 | GEO