Rca-T78 vs, Rca-S78
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA481568 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcription profiiling of arabidopsis transgenic Rca-T78S comparing Control WT plant (Rca-T78). Rca is Rubisco activase and Threonine78 residue of Rca is phosphorylated only in the dark. However, Serine substituted Rca (T78S) was phosphorylated even in the light. Thus, Rca-T78 or Rca-T78S expressing plants which were exposed light for an hour were harvested to check gene expression pattern
2018-09-17 | GSE117263 | GEO
Project description:Hepatocytes :MH vs. ProliHH vs. PHH vs. HLC
| PRJNA792566 | ENA
Project description:Comparsion of the secretome of A. baumannii (WT vs gspD vs HlyD1 vs HlyD2 vs RTX)
2022-04-06 | PXD030460 | Pride
Project description:Vector Control vs SNAIL vs SNAIL/FBXO11
| PRJNA219288 | ENA
Project description:Dementia Comparison: VaD vs. AD vs. Controls
| PRJNA503386 | ENA
Project description:A. baumannii UPAB1 secretome analysis of hlyD1 vs Wt and hlyD2 vs Wt.
2021-08-09 | PXD024736 | Pride
Project description:Human PBMCs: Healthy vs Diabetic nephropathy vs ESRD
| PRJNA595989 | ENA
Project description:In the neonatal liver, a peak of type 2 deiodinase (D2) activity accelerates local T3 production and the expression of thyroid hormone (TH)-responsive genes. Here we show that this acute increase in T3 signaling permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increased H3K9me3 levels during post-natal days 1-5 (P1-P5) in discrete chromatin areas, and methylation of 1,508 DNA sites (H-sites) that remained in the adult mouse liver. These sites were associated with 1,551 areas of reduced chromatin accessibility (RCA; Atac-seq) within core promoters and 2,426 within intergenic regions, with reduction in the expression of 1,525 genes (RNA-seq). There was strong correlation between H-sites and RCA sites (r=0.85; p<0.0002), suggesting a cause-effect relationship. The analysis of chromosome conformation capture (Hi-C) data revealed a set of 57 repressed genes that have a promoter RCA in close contact with an intergenic RCA ~300 Kbp apart, including Foxa2 that plays an important role during development. Thus, the post-natal surge in hepatic D2 activity and TH-signaling prevents discrete DNA methylation and modifies the transcriptome of the adult mouse. This explains how the systemic T3 hormone acts locally during development to define future chromatin accessibility and expression of critically relevant hepatic genes.
2021-06-18 | GSE162929 | GEO
Project description:In the neonatal liver, a peak of type 2 deiodinase (D2) activity accelerates local T3 production and the expression of thyroid hormone (TH)-responsive genes. Here we show that this acute increase in T3 signaling permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increased H3K9me3 levels during post-natal days 1-5 (P1-P5) in discrete chromatin areas, and methylation of 1,508 DNA sites (H-sites) that remained in the adult mouse liver. These sites were associated with 1,551 areas of reduced chromatin accessibility (RCA; Atac-seq) within core promoters and 2,426 within intergenic regions, with reduction in the expression of 1,525 genes (RNA-seq). There was strong correlation between H-sites and RCA sites (r=0.85; p<0.0002), suggesting a cause-effect relationship. The analysis of chromosome conformation capture (Hi-C) data revealed a set of 57 repressed genes that have a promoter RCA in close contact with an intergenic RCA ~300 Kbp apart, including Foxa2 that plays an important role during development. Thus, the post-natal surge in hepatic D2 activity and TH-signaling prevents discrete DNA methylation and modifies the transcriptome of the adult mouse. This explains how the systemic T3 hormone acts locally during development to define future chromatin accessibility and expression of critically relevant hepatic genes.
2021-06-18 | GSE162887 | GEO