Project description:The genes had different expression between healthy people and acute myocardial infarction.We aimed to identify the differentially expressed genes involved in acute myocardial infarction in Northeast Chinese Han people. We used microarrays to detail the global programme of gene expression to identify the differentially gene between the patients with acute myocardial infarction and healthy people in Northeast Chinese Han people
Project description:The genetics, social, cultural and environmental factors pose a great challenge for the diagnosis and treatment of coronary heart disease among different racial groups. We aimed to identify the differentially expressed genes involved in coronary heart disease in Chinese Han people as an aid for screening and diagnosing coronary heart disease. We used microarrays to detail the global programme of gene expression to identify the differentially gene between the patients with coronary heart disease and healthy people in Chinese Han people Three patients with coronary heart disease and three healthy people in Chinese Han people were recruited,total RNA of each samples were extracted from peripheral blood to hybridize with Affymetrix microarrays.
Project description:The genetics, social, cultural and environmental factors pose a great challenge for the diagnosis and treatment of coronary heart disease among different racial groups. We aimed to identify the differentially expressed genes involved in coronary heart disease in Chinese Han people as an aid for screening and diagnosing coronary heart disease. We used microarrays to detail the global programme of gene expression to identify the differentially gene between the patients with coronary heart disease and healthy people in Chinese Han people
Project description:<p>As people are being widely exposed to microplastics (MPs), it is urgent to elucidate their toxicity mechanisms and identify intervention strategies to mitigate their adverse effects. This study firstly designed a two-phase population trial, comprising a pilot population (n = 151) to investigate the MP toxicity mechanisms and a 28-day randomized, double-blind, placebo-controlled trial (n = 98) evaluating the effects of an intervention with composite polyphenols (CP). By integrating a multi-omics approach with phenotype, this study found that MPs could affect specific inflammation and lipid indicators. The underlying mechanism was related to downregulated phosphatidylcholine (PC) 22:5/0:0 and stearidonic acid caused by gut microbiota disruption. CP intervention could mitigate the increase in pro-inflammatory indicators associated with high MP exposure by modulating gut microbiota and up-regulating the glycerophospholipid metabolism and arginine biosynthesis pathways. The gut microorganism Sutterella and plasma metabolite PC (22:5/0:0) may serve as potential targets for this protective action.</p>
