Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next Generation Sequencing Facilitates Quantitative Analysis Of Wild Type And Epithelium-specific Cox10-/- Renal Transcriptomes

ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis Of Wild Type And Epithelium-specific Cox10-/- Renal Transcriptomes

PROVIDER: PRJNA482938 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7601270_1.fastq.gz	Fastqsanger.gz
	SRR7601270_2.fastq.gz	Fastqsanger.gz
	SRR7601271_1.fastq.gz	Fastqsanger.gz
	SRR7601271_2.fastq.gz	Fastqsanger.gz
	SRR7601272_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Next Generation Sequencing Facilitates Quantitative Analysis Of Wild Type And Epithelium-specific Cox10-/- Renal Transcriptomes

Project description:Description: We find multiple evidence that mitochondria are directly and indirectly involved in the pathologic activation of cellular innate immunity. Previously, studies have shown that pathologic type I interferon signatures promote autoimmune diseases and noted mitochondrial and mtDNA dysregulation in chronic inflammatory diseases. Based upon previous data from our lab and others, we anticipated a direct link between the mitochondrial dysfunction and the elevated production of type I interferon or the increase of other innate immune signatures in chronic and general inflammatory diseases. In this project, we wished to test our overall hypothesis that inhibition of mtDNA-mediated immune activation pathway is a promising pharmacological target for chronic inflammatory diseases. To pursue this goal, we developed a murine conditional knockout model, where kidney epithelial cells show dysfunctioning mitochondrial phenotype, and verified that this mouse model has lethal kidney failure with features of chronic kidney disease. By using systems biology approaches, we aimed to examine which genes are regulated in the kidney with dysfunctioning mitochondrial phenotype and identify the main pathways leading to the chronic autoimmune disease. Results: We found that interferon-stimulated genes are upregulated in Cox10 mouse kidney. Likely, mitochondrial dysregulation and mtDNA release induces expression of genes known as interferon-stimulated genes (IGS) (West et al., Nature 2015).

2018-07-27 | GSE117681 | GEO

Pegvisomant-treated mouse prostate epithelium renal grafts

Project description:Pegvisomant-treated mouse prostate epithelium renal grafts

| PRJNA779386 | ENA

Single nuclei sequencing in wild-type and Cox10-/- regenerating liver.

Project description:We report single nuclei sequencing in wild-type and Cox10-/- regenerating mouse livers.

2023-07-02 | GSE236043 | GEO

H3K27ac ChIP-seq in wild-type and Cox10-/- regenerating liver.

Project description:We report here the genome-wide deposition of H3K27ac marks in wild-type and Cox10-/- regenerating mouse livers.

2023-07-01 | GSE235879 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of MYC+ and MYC+; SETD2-/- Renal Tubular Cells Transcriptomes

Project description:To get an insight into the mechanism of how SETD2 ablation promotes ccRCC, we performed RNA-seq using the renal tubules isolated from MYC+; SETD2-/- mice compared with their control MYC+ littermates.

2020-12-31 | GSE125381 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of MYC+ and MYC+ SETD2-/- Renal Tubular Cells Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of MYC+ and MYC+ SETD2-/- Renal Tubular Cells Transcriptomes

| PRJNA516015 | ENA

RNA-seq of wild-type and Cox10-/- muscle stem cells (mouse)

Project description:We report the transcriptome changes in purified mouse muscle stem cells in response to deletion of the Cox10 gene. This study identifies changes in the muscle stem cell population in response to mitochondrial dysfunction.

2021-07-29 | GSE180867 | GEO

Mouse heart proteomics in Oma1 and Cox10 deficient mice

Project description:Cardiomyopathy and heart failure are common manifestations in mitochondrial disease caused by deficiencies in the oxidative phosphorylation system of mitochondria (OXPHOS). Here, we demonstrate that the cardiac-specific loss of the assembly factor Cox10 of the cytochrome c oxidase causes mitochondrial cardiomyopathy in mice, which is associated with OXPHOS deficiency, lysosomal defects and an aberrant mitochondrial morphology and ultrastructure. We demonstrate activation of the mitochondrial peptidase Oma1 in Cox10-/- mice, which results in mitochondrial fragmentation and induction of the integrated stress response (ISR) along the Oma1-Dele1-Atf4 signalling axis. Ablation of Oma1 or Dele1 in Cox10-/- mice aggravates cardiomyopathy. ISR inhibition impairs the cardiac glutathione metabolism, decreases the levels of the glutathione peroxidase Gpx4 and increases lipid peroxidation in the heart, ultimately culminating in ferroptosis. Our results demonstrate a protective role of the Oma1-mediated ISR in mitochondrial cardiomyopathy and link ferroptosis to OXPHOS deficiency and mitochondrial disease.

2022-07-27 | PXD031641 | Pride

Next-generation sequencing facilitates quantitative analysis of wild and acute renal failure mice

Project description:Next-generation sequencing facilitates quantitative analysis of wild and acute renal failure mice

| PRJNA761759 | ENA

Cox10 is Required for Natural Killer Cell Expansion and Memory in Response to Viral Infection

Project description:Single-cell RNA-sequencing revealed increased pAMPK signaling and a unique gene expression signature. Our data demonstrate that Cox10 is required by NK cells to expand in response to Ly49H stimulation during MCMV infection.

2021-04-17 | GSE149659 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data