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Microbiota Depletion Impairs Adaptive Thermogenesis of Both Brown and Beige Adipose Tissue

ABSTRACT: Microbiota Depletion Impairs Adaptive Thermogenesis of Both Brown and Beige Adipose Tissue

PROVIDER: PRJNA483405 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7618850_1.fastq.gz	Fastqsanger.gz
	SRR7618850_2.fastq.gz	Fastqsanger.gz
	SRR7618860_1.fastq.gz	Fastqsanger.gz
	SRR7618860_2.fastq.gz	Fastqsanger.gz
	SRR7618870_1.fastq.gz	Fastqsanger.gz

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The Histone Methyltransferase SUV420H2 Regulates Brown and Beige Adipocyte Thermogenesis

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Project description:We reported that both conventional and adipose-specific Naa10p deletions in mice result in increased energy expenditure, thermogenesis, beige adipocyte differentiation and activation. Mechanistically, Naa10p acetylates the N-terminus of Pgc1α and prevents it from interacting with Ppar to activate key genes, such as Ucp1, involved in beige adipocyte function. We used microarrays to profile the gene expression changes by Naa10p KO in inguinal white adipose tissues (iWATs) derived from mice fed with high fat diet for 15 weeks.

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