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The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (Adherent MCF7 cells)

ABSTRACT: The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (Adherent MCF7 cells)

PROVIDER: PRJNA483784 | ENA |

REPOSITORIES: ENA

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The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (Adherent MCF7 cells)

Project description:Since the thyroid hormone receptor β (TRβ) appears to suppress breast tumor growth and metastasis, we have analyzed the possibility that this receptor could affect cancer stem cell biology using TRβ-expressing MCF-7 cells (MCF7-TRβ cells) treated with the thyroid hormone T3.

2019-12-05 | GSE117949 | GEO

The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (mammospheres from MCF7 cells)

Project description:The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (mammospheres from MCF7 cells)

| PRJNA483782 | ENA

The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells (mammospheres from MCF7 cells)

Project description:Since the thyroid hormone receptor β (TRβ) appears to suppress breast tumor growth and metastasis, we have analyzed the possibility that this receptor could affect cancer stem cell biology using mammospheres from TRβ-expressing MCF-7 cells (MCF7-TRβ cells) treated with the thyroid hormone T3.

2019-12-05 | GSE117950 | GEO

The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells

Project description:The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells

| PRJNA483781 | ENA

Thyroid Hormone Receptor ? Inhibits Self-Renewal Capacity of Breast Cancer Stem Cells.

Project description:Background: A subpopulation of cancer stem cells (CSCs) with capacity for self-renewal is believed to drive initiation, progression, and relapse of breast tumors. Methods: Since the thyroid hormone receptor ? (TR?) appears to suppress breast tumor growth and metastasis, we have analyzed the possibility that TR? could affect the CSC population using MCF-7 cells grown under adherent conditions or as mammospheres, as well as inoculation into immunodeficient mice. Results: Treatment of TR?-expressing MCF-7 cells (MCF7-TR? cells) with the thyroid hormone triiodothyronine (T3) decreased significantly CD44+/CD24- and ALDH+ cell subpopulations, the efficiency of mammosphere formation, the self-renewal capacity of CSCs in limiting dilution assays, the expression of the pluripotency factors in the mammospheres, and tumor initiating capacity in immunodeficient mice, indicating that the hormone reduces the CSC population present within the bulk MCF7-TR? cultures. T3 also decreased migration and invasion, a hallmark of CSCs. Transcriptome analysis showed downregulation of the estrogen receptor alpha (ER?) and ER-responsive genes by T3. Furthermore, among the T3-repressed genes, there was an enrichment in genes containing binding sites for transcription factors that are key determinants of luminal-type breast cancers and are required for ER binding to chromatin. Conclusion: We demonstrate a novel role of TR? in the biology of CSCs that may be related to its action as a tumor suppressor in breast cancer.

| S-EPMC6998057 | biostudies-literature

Expression data of Mesenchymal Stroma Cells (MSC)-adherent and non-adherent, human cord blood-derived, hematopoietic CD34 cells

2016-05-16 | GSE78216 | GEO

Expression data of Mesenchymal Stroma Cells (MSC)-adherent and non-adherent, human cord blood-derived, hematopoietic CD34 cells

Project description:MSC-adherent hematopoietic stem and progenotir cells (HSPC) express adhesion-associated genes at higher levels than non-adherent cells while cell-cycle and differentiation-associated genes are not significantly changed between the two cell populations. We used microarray to confirm identity of MSC-adherent and non-adherent cord blood-derived HSPCs and to exclude that cell cycle and differentiation affect adhesive capacity. CD34 positive cells were isolated from human cord blood (not older than 24h), expanded for 3 days and assayed for the adhesion to MSC. The adherent and non-adherent live CD34+ cells were sorted and total RNA was extracted.

2016-05-16 | E-GEOD-78216 | biostudies-arrayexpress

The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-05 | GSE117951 | GEO

Transcriptional profiing of cultured adherent and non-adherent monocytes

Project description:Transcriptional profiing of cultured adherent and non-adherent monocytes

| PRJNA679607 | ENA

Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials

Project description:Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials

| PRJNA531434 | ENA