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Effect of Fumonisin B1 on hepatic transcriptome in WT and LXR KO female mice

ABSTRACT: Effect of Fumonisin B1 on hepatic transcriptome in WT and LXR KO female mice

PROVIDER: PRJNA484331 | ENA |

REPOSITORIES: ENA

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Effect of Fumonisin B1 exposure on hepatic gene expression in mice fed a regular diet (CHOW) and in mice fed a High Fat Diet (HFD).

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Effect of Fumonisin B1 on hepatic transcriptome in WT and LXR KO female mice

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Differential gene expression of Arabidopsis in response to fumonisin B1 and exogenous ATP treatments

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Transcriptome changes of fission yeast cells exposed to fumonisin B1 or co-cultured with Fusarium verticillioides

Project description:Fusarium verticillioides poses a high food safety risk worldwide due to its mycotoxin production. Successful control of Fusaria may rely on promising biocontrol agents, including yeasts. Although the fission yeast Schizosaccharomyces pombe tolerated Fusarium mycotoxins well, including zearalenone, T2, deoxynivalenol, and fumonisins (FUMs), it did not significantly inhibit the growth of F. verticillioides. Meanwhile fumonisin B1 (FB1) supplementation did not decrease S. pombe cell density in submerged liquid cultures, the colony-forming capability of the yeast was reduced. RNA sequencing showed that S. pombe genes involved in cell adhesion and flocculation were down-regulated after FB1 exposure. In addition, the expression of several hydrolase genes was also altered. In co-cultures with F. verticillioides, genes encoding oxidoreductases and hydrolases and those linked to purine nucleotide metabolisms were down-regulated, while the expression of genes involved in membrane and transport processes was increased. The expression of several F. verticillioides genes also changed after co-cultivation. Oxidoreductase, transmembrane transport, and purine metabolism genes were up-regulated under co-culturing, meanwhile hydrolase genes, together with carbon metabolism and polysaccharide catabolism genes were down-regulated. Co-cultivation also decreased fumonisin production via the down-regulation of genes FUM19, FUM21, and FvATFA encoding the fumonisin transporter, a local Zn(II)2Cys6-type transcriptional regulator and an important global regulator bZIP-type transcription factor, respectively. Although further experiments should clarify the mechanism of the fission yeast-elicited inhibition of fumonisin production, these results may pave the way for the development and implementation of novel, innovative approaches to control mycotoxin production by F. verticillioides in the feed and food chain.

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