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The Effect of PRMT5 deficiency on thymic iNKT cells

ABSTRACT: The Effect of PRMT5 deficiency on thymic iNKT cells

PROVIDER: PRJNA484635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7646280.fastq.gz	Fastqsanger.gz
	SRR7646282.fastq.gz	Fastqsanger.gz
	SRR7646276.fastq.gz	Fastqsanger.gz
	SRR7646278.fastq.gz	Fastqsanger.gz

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The Effect of PRMT5 deficiency on thymic iNKT cells

Project description:Protein arginine methylation is a post-translational modification catalyzed by protein arginine methyltransferase (PRMT). To elucidate the role of PRMT5 in T cells, we generated T-cell specific PRMT5-deficient mice (Prmt5 flox/d Cd4-Cre mice) and found a severe loss of thymic iNKT cells as well as a reduced number in peripheral CD4+ and CD8+ T cells. As iNKT cells were significantly decreased in the stage 1, 2 and 3 of developmental stages, RNA-seq was performed using stage 1 iNKT cells of control and PRMT5-deficient mice. This transcriptome analysis will provide mechanistic insight into how PRMT5 contributes to thymic iNKT cell development.

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