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Placenta and uterus transcriptomes from transgenic mice expressing human corticotropin-releasing hormone in placenta

ABSTRACT: Placenta and uterus transcriptomes from transgenic mice expressing human corticotropin-releasing hormone in placenta

PROVIDER: PRJNA485077 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7659010_1.fastq.gz	Fastqsanger.gz
	SRR7659010_2.fastq.gz	Fastqsanger.gz
	SRR7659020_1.fastq.gz	Fastqsanger.gz
	SRR7659020_2.fastq.gz	Fastqsanger.gz
	SRR7659001_1.fastq.gz	Fastqsanger.gz

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Placenta and uterus transcriptomes from transgenic mice expressing human corticotropin-releasing hormone in placenta

Project description:Purpose: Parturition is delayed by approximately 12 hours in transgenic mice expressing human corticotropin-releasing hormone (CRH) in placenta. The goal of the study was to identify the pathways in reproductive tissues (uterus and placenta) altered by placental expression of human CRH. Methods: Human BAC RP11-366K18 (CHORI) containing human CRH and cis-regulatory region was inserted into the mouse genome by microinjection and random integration to create the BAC1 line. The CRISPR/Cas9 system was used to delete a CRH regulatory element from the BAC1 line to create the CR1 line, eliminating expression of CRH in placenta. Total expression of uterus and placenta by RNA-seq at embryonic day 18.5 were compared between BAC1, CR1, and nontransgenic mice. Results: Genes known to be associated with luteolysis and initiation of parturition (Cav1, Gja1, Oxtr, Ptgs1, Ptgs2) were not differentially expressed in uterus of this model. Conclusions: CRH-mediated delay of parturition is likely independent of luteolysis.

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Primary Trophoblasts treated with Corticotropin Releasing Hormone (CRH)

Project description:Primary trophoblast cells were treated with corticotropin releasing hormone (CRH) and then subjected to RNA extraction and sequencing.

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Primary Trophoblasts treated with Corticotropin Releasing Hormone (CRH)

Project description:Primary Trophoblasts treated with Corticotropin Releasing Hormone (CRH)

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Single-cell transcriptome analysis of secretagogin mRNA expressing cells from the mouse hypothalamic paraventricular nucleus

Project description:The molecular mechanism regulating phasic corticotropin-releasing hormone (CRH) release from parvocellular neurons (PVN) remains poorly understood. Here, we find a cohort of parvocellular cells interspersed with magnocellular PVN neurons expressing secretagogin. Single-cell transcriptome analysis combined with protein interactome profiling identifies secretagogin neurons as a distinct CRH-releasing neuron population reliant on secretagoginM-bM-^@M-^Ys Ca2+ sensor properties and protein interactions with the vesicular traffic and exocytosis release machineries to liberate this key hypothalamic releasing hormone. single cells from the PVN region juvenile (21-28 days) mice were dissected and subject to whole transcriptome analysis

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Mastication stimuli regulate the heart beat rate through the rhythmic regulation by hypothalamic-autonomic system in the weaning stage rat

Project description:Using DNA microarray analysis, vasopressin, cocaine-amphetamine regulated transcript prepropeptide, corticotropin releasing hormone, and thyrotropin releasing hormone, all of which are involved in the sympathetic activation of heart rate, were found to be down-regulated in the chow diet group. Our results provided the molecular and physiological bases for understanding the autonomic nervous regulation of cardiovascular function by the mastication stimuli.

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Project description:The molecular mechanism regulating phasic corticotropin-releasing hormone (CRH) release from parvocellular neurons (PVN) remains poorly understood. Here, we find a cohort of parvocellular cells interspersed with magnocellular PVN neurons expressing secretagogin. Single-cell transcriptome analysis combined with protein interactome profiling identifies secretagogin neurons as a distinct CRH-releasing neuron population reliant on secretagogin’s Ca2+ sensor properties and protein interactions with the vesicular traffic and exocytosis release machineries to liberate this key hypothalamic releasing hormone.

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Project description:The histone H3-lysine 4-methyltransferase Mll4 governs the development of growth hormone-releasing hormone-producing neurons

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Transcriptional effect of CRH on MCF7 estrogen receptor signalling

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Transcriptional changes in human haematopoietic stem and progenitor cells（HSPCs） from umbilical cord blood in response to the corticotropin releasing hormone（CRH）

Project description:Transcriptional changes in human haematopoietic stem and progenitor cells（HSPCs） from umbilical cord blood in response to the corticotropin releasing hormone（CRH）

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Transcriptional effect of CRH on MCF7 estrogen receptor signalling

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