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RNA-seq in livers of wild-type (WT) controls, PiZ and PIZ mice deleted for Chop (PiZ/Chop-/-)

ABSTRACT: RNA-seq in livers of wild-type (WT) controls, PiZ and PIZ mice deleted for Chop (PiZ/Chop-/-)

PROVIDER: PRJNA485117 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7659060.fastq.gz	Fastqsanger.gz
	SRR7659061.fastq.gz	Fastqsanger.gz
	SRR7659062.fastq.gz	Fastqsanger.gz
	SRR7659063.fastq.gz	Fastqsanger.gz
	SRR7659064.fastq.gz	Fastqsanger.gz

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RNA-seq in livers of wild-type (WT) controls, PiZ and PIZ mice deleted for Chop (PiZ/Chop-/-)

Project description:Transgenic PiZ mice have been genetically engineered to express ATZ and have been a valuable experimental model for liver disease due to AAT polymerization. ATZ accumulates in these mice within the endoplamic reticulum (ER) of hepatocytes in a nearly identical manner to livers of affected patients. To investigate the role of the transcription factor CHOP in the pathogenesis of liver damage induced by ATZ, we performed RNA-seq in livers of 6-week-old wild type, PiZ and PiZ mice deleted for Chop. All groups were matched for the strain, age, and the gender.

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