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Multi Omics analysis of fibrotic kidneys in two mouse models [miRNA-Seq]

ABSTRACT: Multi Omics analysis of fibrotic kidneys in two mouse models [miRNA-Seq]

PROVIDER: PRJNA485263 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7663650.fastq.gz	Fastqsanger.gz
	SRR7663660.fastq.gz	Fastqsanger.gz
	SRR7663651.fastq.gz	Fastqsanger.gz
	SRR7663661.fastq.gz	Fastqsanger.gz
	SRR7663652.fastq.gz	Fastqsanger.gz

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Multi Omics analysis of fibrotic kidneys in two mouse models

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Project description:Kidney fibrosis represents an urgent unmet clinical need due to the lack of effective therapies and inadequate understanding of the molecular pathogenesis. We have generated a comprehensive and integrated multi-omics data set (proteomics, mRNA and small RNA transcriptomics) of fibrotic kidneys that is searchable through a user-friendly web application. Two commonly used mouse models were utilized: a reversible chemical-induced injury model (folic acid (FA) induced nephropathy) and an irreversible surgically-induced fibrosis model (unilateral ureteral obstruction (UUO)). mRNA and small RNA sequencing as well as 10-plex tandem mass tag (TMT) proteomics were performed with kidney samples from different time points over the course of fibrosis development. The bioinformatics workflow used to process, technically validate, and integrate the single data sets will be described. In summary, we present temporal and integrated multi-omics data from fibrotic mouse kidneys that are accessible through an interrogation tool to provide a searchable transcriptome and proteome for kidney fibrosis researchers.

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Multi omics analysis of fibrotic kidneys in two mouse models.

Project description:Kidney fibrosis represents an urgent unmet clinical need due to the lack of effective therapies and an inadequate understanding of the molecular pathogenesis. We have generated a comprehensive and combined multi-omics dataset (proteomics, mRNA and small RNA transcriptomics) of fibrotic kidneys that is searchable through a user-friendly web application: http://hbcreports.med.harvard.edu/fmm/ . Two commonly used mouse models were utilized: a reversible chemical-induced injury model (folic acid (FA) induced nephropathy) and an irreversible surgically-induced fibrosis model (unilateral ureteral obstruction (UUO)). mRNA and small RNA sequencing, as well as 10-plex tandem mass tag (TMT) proteomics were performed with kidney samples from different time points over the course of fibrosis development. The bioinformatics workflow used to process, technically validate, and combine the single omics data will be described. In summary, we present temporal multi-omics data from fibrotic mouse kidneys that are accessible through an interrogation tool (Mouse Kidney Fibromics browser) to provide a searchable transcriptome and proteome for kidney fibrosis researchers.

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Multi Omics analysis of fibrotic kidneys in two mouse models

Project description:This SuperSeries is composed of the SubSeries listed below.

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