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[Haemophilus] ducreyi strain:35000HP 11/30/11

ABSTRACT: Assessment of the virulence of H. ducreyi 35000HP vs. its derivative (FX548) containing a class II hgbA allele in humans

PROVIDER: PRJNA485483 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7688764_1.fastq.gz	Fastqsanger.gz
	SRR7688764_2.fastq.gz	Fastqsanger.gz

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[Haemophilus] ducreyi strain:FX548 11/30/11

Project description:Assessment of the virulence of H. ducreyi 35000 HP vs its derivative (FX548) containing a class II hgbA allele in humans

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Haemophilus ducreyi 35000HPcpxA gene expression relative to 35000HP

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Project description:To potentially understand how H. ducreyi responds to membrane stress, here we defined RpoE-dependent genes using RNA-Seq. We identified 180 RpoE-dependent genes, of which 98% were upregulated; a major set of these genes encodes homologues of envelope maintenance and repair factors. We also identified and validated a putative RpoE promoter consensus sequence, which was enriched in the majority of RpoE-dependent targets. Comparison of RpoE-dependent genes to those controlled by CpxR showed that each transcription factor regulated a distinct set of genes. Given that RpoE activated a large number of genes encoding envelope maintenance and repair factors and CpxRA represses genes encoding envelope-localized proteins, these data suggest that RpoE and CpxRA appear to play distinct yet complementary roles in regulating envelope homeostasis in H. ducreyi. RNA of Haemophilus ducreyi 35000HP wild-type strain containing a rpoE inducible plasmid and wild-type strain containing a control plasmid were collected at 0 minutes, 5 minutes, and 10 minutes after induction in quadruplicate.

2015-11-21 | E-GEOD-75238 | biostudies-arrayexpress

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Project description:Comparative analysis of the global gene expression of a Haemophilus ducreyi 35000HP cpxA deletion mutant relative to the wild type strain After the cpxA mutant was generated, both strain were grown in Columbia Broth. After 8 hr of growth RNA wa isolated and processed for DNA microarray analysis. This study includes three biological replicates (paired samples), and all three were subjected to dye swap.

2011-05-03 | E-GEOD-21788 | biostudies-arrayexpress

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Project description:H. ducreyi 35000HP grown in the presence or absence of FCS

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Project description:To better understand the molecular mechanisms underlying Haemophilus ducreyi infection in humans, here we determined the transcriptional profile of H. ducreyi in human lesions using RNA-Seq and compared it to that of in vitro growth. We were able to show that the in vivo transcriptome did not resemble that of in vitro growth. Compared to the inoculum, H. ducreyi harvested from pustules differentially expressed ~120 genes, of which 68 were upregulated. A large proportion of the upregulated genes encoded homologs of proteins involved in nutrient transport, alternative carbon pathways, growth arrest response, heat shock response, and DNA recombination. H. ducreyi upregulated few genes or operons (hgbA, flp-tad, and lspB-lspA2) required for human infection; expression of these genes is known to increase under nutrient stress. Homologs of several genes involved in anaerobic metabolism and ascorbate utilization were upregulated in vivo, suggesting that the organism is adjusting its metabolism to anaerobiosis in vivo.

2015-11-21 | GSE75236 | GEO

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