Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA

ABSTRACT: LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA

PROVIDER: PRJNA485531 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7685820.fastq.gz	Fastqsanger.gz
	SRR7685830_1.fastq.gz	Fastqsanger.gz
	SRR7685830_2.fastq.gz	Fastqsanger.gz
	SRR7685840.fastq.gz	Fastqsanger.gz
	SRR7685850.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 95

Similar Datasets

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RIP-seq]

Project description:Long noncoding RNAs (lncRNAs) cause Polycomb Repressive Complexes (PRCs) to spread over broad regions of the mammalian genome. We report that in mouse trophoblast stem cells, the Kcnq1ot1 and Airn lncRNAs induce PRC-dependent chromatin modifications over multi-megabase domains. Throughout the Airn-targeted domain, extent of PRC-dependent modification correlated with intra-nuclear distance to the Airn locus, pre-existing genome architecture, and the abundance of Airn itself. Specific CpG islands displayed characteristics indicating that they nucleate the spread of PRCs upon exposure to Airn. Chromatin environments surrounding Xist, Airn, and Kcnq1ot1 suggest common mechanisms of PRC engagement and spreading. Our data indicate that lncRNA potency can be tightly linked to lncRNA abundance, and that within lncRNA-targeted domains, PRCs are recruited to CpG islands via lncRNA-independent mechanisms. We propose that CpG islands that autonomously recruit PRCs interact with lncRNAs and their associated proteins through 3-dimensional space to nucleate the spread of PRCs in lncRNA-targeted domains.

2019-06-27 | GSE129496 | GEO

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [ChIP-Seq]

2019-06-27 | GSE118399 | GEO

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RNA-Seq]

2019-06-27 | GSE118401 | GEO

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RNA-Seq]

Project description:LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RNA-Seq]

| PRJNA485532 | ENA

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [ChIP-Seq]

Project description:LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [ChIP-Seq]

| PRJNA485533 | ENA

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RIP-seq]

Project description:LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA [RIP-seq]

| PRJNA531506 | ENA

lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.

Project description:Long noncoding RNAs (lncRNAs) cause Polycomb repressive complexes (PRCs) to spread over broad regions of the mammalian genome. We report that in mouse trophoblast stem cells, the Airn and Kcnq1ot1 lncRNAs induce PRC-dependent chromatin modifications over multi-megabase domains. Throughout the Airn-targeted domain, the extent of PRC-dependent modification correlated with intra-nuclear distance to the Airn locus, preexisting genome architecture, and the abundance of Airn itself. Specific CpG islands (CGIs) displayed characteristics indicating that they nucleate the spread of PRCs upon exposure to Airn. Chromatin environments surrounding Xist, Airn, and Kcnq1ot1 suggest common mechanisms of PRC engagement and spreading. Our data indicate that lncRNA potency can be tightly linked to lncRNA abundance and that within lncRNA-targeted domains, PRCs are recruited to CGIs via lncRNA-independent mechanisms. We propose that CGIs that autonomously recruit PRCs interact with lncRNAs and their associated proteins through three-dimensional space to nucleate the spread of PRCs in lncRNA-targeted domains.

| S-EPMC6688959 | biostudies-literature

LncRNA-induced spread of Polycomb controlled by genome architecture, RNA abundance, and CpG island DNA

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-06-27 | GSE118402 | GEO

CpG Island Structure and Trithorax/Polycomb Chromatin Domains in Human Cells

Project description:TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG islands at genes predict occupancy of H3K4me3 and H3K27me3, and these "bivalent" chromatin domains precisely span the boundaries of CpG island clusters.

2012-07-06 | GSE39137 | GEO

CpG Island Structure and Trithorax/Polycomb Chromatin Domains in Human Cells

2012-07-06 | E-GEOD-39137 | biostudies-arrayexpress