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MiRNA-Seq profiling of nasopharyngeal carcinoma (NPC) and normal control samples

ABSTRACT: miRNA-Seq profiling of nasopharyngeal carcinoma (NPC) and normal control samples

PROVIDER: PRJNA486534 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7707750.fastq.gz	Fastqsanger.gz
	SRR7707751.fastq.gz	Fastqsanger.gz
	SRR7707752.fastq.gz	Fastqsanger.gz
	SRR7707753.fastq.gz	Fastqsanger.gz
	SRR7707744.fastq.gz	Fastqsanger.gz

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Project description:To understand the genes and pathways that may potentially drive nasopharyngeal carcinoma (NPC) pathogenesis, we sought out to analyze the transcriptomic data from the disease and control samples. We used RNA-sequencing based gene expression data to identify genes differentially expressed between NPC and normal controls and then characterize the gene ontology and pathways down- or up-regulated in the disease samples.

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Project description:Nasopharyngeal carcinoma (NPC) is rare malignancy in most parts around the world but common in Southern China and Southeast Asia, Annually, approximately 80,000 new NPC cases and 50,000 deaths are reported worldwide. In NPC, recent advances have shown that many genes that are predominantly or even exclusively silenced by DNA methylation in epithelial cells during pathogenesis of NPC. However, the causal relationship between DNA methylation status and outcome in NPC remains not well understood. To investigate this problem, we used Illumina 450K BeadChips to examined methylation patterns and survival in NPC. and ultimately provided insight into prognostic value of DNA methylation in NPC clinical management. We employed Illumina Human Methylation450K Beadchip to analyze a genome-wide of DNA methylation in a cohort of 48 samples (between 24 nasopharyngeal carcinoma tissues and 24 normal nasopharyngeal epithelial tissues) to identify aberrant methylation genes.

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