Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Molecular profiling of non-small cell lung cancer organoids

PROVIDER: PRJNA487223 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7739530_1.fastq.gz	Fastqsanger.gz
	SRR7739530_2.fastq.gz	Fastqsanger.gz
	SRR7739540_1.fastq.gz	Fastqsanger.gz
	SRR7739540_2.fastq.gz	Fastqsanger.gz
	SRR7739531_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Homo sapiens

Project description:Non Small Cell Lung Cancer

| PRJNA90997 | ENA

Establishment and disease modeling of non-small cell lung cancer organoids

Project description:Establishment and disease modeling of non-small cell lung cancer organoids

| PRJNA487654 | ENA

Project description:Standardization of Molecular Diagnostic Testing for Non-small Cell Lung Cancer

| PRJNA809708 | ENA

Project description:Lung microbiome of non-small cell lung cancer

| PRJNA647170 | ENA

Project description:Lung microbiome in non-small cell lung cancer

| PRJNA773392 | ENA

Cooperation Between PRMT1 and PRMT6 Drives Lung Cancer Health Disparities Among Black/African American Men

Project description:SUMMARY Non-Hispanic Black/African American (Black/AA) men in the United States have disproportionally higher incidence and mortality rates of lung cancer compared to non-Hispanic White (NHW) men. Biological factors are believed to play critical roles in driving the disparities. Nevertheless, large-scale genomic studies fail to identify significant somatic differences in lung cancer driver genes contributing to the disparities. Elevated expression of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis is observed in many cancer types. Here, we observed a higher PRMT6 expression in lung cancer of Black/AA men compared to NHW men. PRMT6 formed a heteromer complex with PRMT1 to catalyze arginine methylation of interleukin enhancer-binding factor 2 essential for cell proliferation. Disrupting PRMT1/PRMT6 heteromer complex by a competitive peptide reduced cell proliferation in non-small cell lung cancer cell lines and lung cancer patient-derived organoids. This work implicates that PRMT1/PRMT6 heteromer complex contributes to poorer lung cancer outcomes in Black/AA men vs. NHW men that could serve as a target to eliminate cancer health disparities.

2023-12-15 | MSV000093674 | MassIVE

Epigenetic Rewiring of Metastatic Cancer to the Brain: Focus on Lung and Colon Cancers

Project description:Genome wide DNA methylation profiling of brain metastasis from colorectal and lung cancer. The Illumina Infinium MethylationEPIC was used to obtain DNA methylation profiles across approximately 850,000 CpGs in brain metastasis samples. Samples included 1 breast ductal invasive carcinoma, 4 colon adenocarcinoma, 1 melanoma, 1 multiple mieloma, 7 non small cell lung cancer adenocarcinoma, 3 non small cell lung cancer G3, 4 non small cell lung cancer SCC, 1 prostate cancer adenocarcinoma and 1 serous carcinoma.

2023-12-17 | GSE249157 | GEO

Project description:Non-small Cell Lung Cancer (qRT-PCR)

| PRJNA107251 | ENA

Homo sapiens

Project description:Molecular Classification and Prediction of Survival in Non-Small-Cell Lung Cancer

| PRJNA107013 | ENA

Postoperative circulating tumor DNA monitoring for stage I-III non-small cell lung cancer

Project description:The target sequecing vcf data of tumor and curculating tumor DNA for non-small cell lung cancer patients.

2022-05-09 | PRJEB52694 | EVA