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Toxicity of LCDD monoclonal Ig free light chains on renal glomeruli

ABSTRACT: Toxicity of LCDD monoclonal Ig free light chains on renal glomeruli

PROVIDER: PRJNA487942 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7755580_1.fastq.gz	Fastqsanger.gz
	SRR7755580_2.fastq.gz	Fastqsanger.gz
	SRR7755581_1.fastq.gz	Fastqsanger.gz
	SRR7755581_2.fastq.gz	Fastqsanger.gz
	SRR7755572_1.fastq.gz	Fastqsanger.gz

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Toxicity of LCDD monoclonal Ig free light chains on renal glomeruli

Project description:We analyzed the transcriptome (RNA-seq) of glomeruli in a mouse model of light chain deposition disease (LCDD) as compared to control mice (WT and DH-LMP2A, the latter producing no complete immunoglobulins, only free Ig light chains). Kidney lesions in LCDD are due to the deposition of an abnormal monoclonal free Ig light chain and comprise progressive thickening of basement membranes (tubular and glomerular) and nodular glomerulosclerosis resembling the lesions observed in diabetic nephropathy. The aim of the present study is to analyse the transcriptomic changes at early steps of glomerulosclerosis.

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Toxicity of LCDD monoclonal Ig free light chains

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Toxicity of LCDD monoclonal Ig free light chains

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Intrinsic toxicity of LCDD monoclonal Ig free light chain on plasma cells (PC)

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