Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO sick expression]

ABSTRACT: Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO sick expression]

PROVIDER: PRJNA488186 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO sick expression]

Project description:The transcriptional regulator Rbpj is involved in T-helper (TH) subset polarization, but its function in Treg cells remains unclear. Here we show that Treg-specific Rbpj deletion leads to splenomegaly and lymphadenopathy despite increased numbers of Treg cells with a polyclonal TCR repertoire. A specific defect of Rbpj-deficient Treg cells in controlling TH2 polarization and B cell responses was observed, leading to the spontaneous formation of germinal centers and a TH2-associated immunoglobulin class switch as well as T-cell polarization into TH2 effector cells. The observed phenotype was environment-dependent and could be induced by infection with parasitic nematodes. Rbpj-deficient Treg cells adopted open chromatin landscapes and gene expression profiles reminiscent of tissue-derived TH2-polarized Treg cells, with a prevailing footprint of transcription factor Gata-3. The over-expression of Ilt3 rendered Rbpj-deficient Treg cells incompatible to specifically restrain TH2 responses, finally leading to severe and fatal lymphoproliferative disease.

2019-01-31 | GSE119111 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO and RbpjWT RNA-seq]

Project description:The transcriptional regulator Rbpj is involved in T-helper (TH) subset polarization, but its function in Treg cells remains unclear. Here we show that Treg-specific Rbpj deletion leads to splenomegaly and lymphadenopathy despite increased numbers of Treg cells with a polyclonal TCR repertoire. A specific defect of Rbpj-deficient Treg cells in controlling TH2 polarization and B cell responses is observed, leading to the spontaneous formation of germinal centers and a TH2-associated immunoglobulin class switch. The observed phenotype is environment-dependent and can be induced by infection with parasitic nematodes. Rbpj-deficient Treg cells adopt open chromatin landscapes and gene expression profiles reminiscent of tissue-derived TH2-polarized Treg cells, with a prevailing footprint of the transcription factor Gata-3. Taken together, our study suggest that Treg cells require Rbpj to specifically restrain TH2 responses, including their own excessive TH2-like differentiation potential.

2019-01-31 | GSE119011 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen Treg and Tconv RbpjKO expression]

2019-01-31 | GSE119155 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [female spleen Treg and Tconv RbpjKO expression]

2019-01-31 | GSE119166 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [lymph nodes RbpjWT and diseased RbpjKO expression]

2019-01-31 | GSE119130 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen Treg and Tconv RbpjKO expression]

Project description:Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen Treg and Tconv RbpjKO expression]

| PRJNA488277 | ENA

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO and RbpjWT RNA-seq]

Project description:Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen RbpjKO and RbpjWT RNA-seq]

| PRJNA487769 | ENA

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [affected and unaffected spleen Treg and Tconv RbpjKO and RbpjWT expression]

2019-01-31 | GSE119167 | GEO

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [lymph nodes RbpjWT and diseased RbpjKO expression]

Project description:Rbpj expression in regulatory T cells is critical for restraining TH2 responses [lymph nodes RbpjWT and diseased RbpjKO expression]

| PRJNA488238 | ENA

Rbpj expression in regulatory T cells is critical for restraining TH2 responses [female spleen Treg and Tconv RbpjKO expression]

Project description:Rbpj expression in regulatory T cells is critical for restraining TH2 responses [female spleen Treg and Tconv RbpjKO expression]

| PRJNA488294 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data