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In utero heat stress alters the offspring epigenome

ABSTRACT: In utero heat stress alters the offspring epigenome

PROVIDER: PRJNA488483 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7767894.fastq.gz	Fastqsanger.gz
	SRR7767895.fastq.gz	Fastqsanger.gz
	SRR7767896.fastq.gz	Fastqsanger.gz
	SRR7767897.fastq.gz	Fastqsanger.gz
	SRR7767898.fastq.gz	Fastqsanger.gz

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In utero heat stress alters the offspring epigenome [methylation]

Project description:In utero heat stress alters the offspring epigenome [methylation]

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In utero heat stress alters the offspring epigenome

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In Utero Heat Stress Alters the Offspring Epigenome.

Project description:Exposure to intrauterine heat stress during late gestation affects offspring performance into adulthood. However, underlying mechanistic links between thermal insult in fetal life and postnatal outcomes are not completely understood. We examined morphology, DNA methylation, and gene expression of liver and mammary gland for bull calves and heifers that were gestated under maternal conditions of heat stress or cooling (i.e. in utero heat stressed vs. in utero cooled calves). Mammary tissue was harvested from dairy heifers during their first lactation and liver from bull calves at birth. The liver of in utero heat stressed bull calves contained more cells and the mammary glands of in utero heat stressed heifers were comprised of smaller alveoli. We identified more than 1,500 CpG sites differently methylated between maternal treatment groups. These CpGs were associated with approximately 400 genes, which play a role in processes, such as development, innate immune defense, cell signaling, and transcription and translation. We also identified over 100 differentially expressed genes in the mammary gland with similar functions. Interestingly, fifty differentially methylated genes were shared by both bull calf liver and heifer mammary gland. Intrauterine heat stress alters the methylation profile of liver and mammary DNA and programs their morphology in postnatal life, which may contribute to the poorer performance of in utero heat stressed calves.

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Maternal methionine supplementation alters the epigenome of the offspring

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Maternal methionine supplementation alters the epigenome of the offspring [RNA-Seq]

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Effect of in utero undernutrition on skeletal muscle gene expression

Project description:In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood. We have used a mouse model of low birth weight generated through 50% food restriction of mouse dams during the third week of gestation. We have studied in utero food restricted offspring and control offspring that were not food restricted in utero in both the ad libitum and calorie restricted states. Gene expression profiling was performed on tibialis anterior muscle from 8 mice per group, pooled in pairs.

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