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Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants

ABSTRACT: Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants

PROVIDER: PRJNA488798 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7774360_1.fastq.gz	Fastqsanger.gz
	SRR7774360_2.fastq.gz	Fastqsanger.gz
	SRR7774361_1.fastq.gz	Fastqsanger.gz
	SRR7774361_2.fastq.gz	Fastqsanger.gz
	SRR7774362_1.fastq.gz	Fastqsanger.gz

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Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants

Project description:RNA-sequencing analysis of periacetabular synovial tissue collected from patients undergoing a revision total hip arthroplasty (rTHA) after failure of a Cobalt Chromium implant. Comparisons were made to periacetabular synovial tissue collected from patients undergoing primary THAs (pTHA). Results: Analysis of tissue biopsies by RNA-sequencing revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling.

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Project description:Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.

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