Project description:To identify the gene regulatory network during heart aging, we used the RNA-seq to analyze the gene expression profile difference between adult mouse heart and aging mouse heart.
Project description:To assess in order to assess potential disparities in gene expression due to developmental differences we performed a comparison between hippocampus and heart tissues from rat and mouse pup (one week old) and adult (10 week old) animals. Using heart and hippocampal tissue from mouse (C57BL/6) and rat (Sprague Dawley) we investigate via microarrays, gene expression divergence at the tissue level between a Brain and a Non-brain tissue. We also investigated any developement difference in gene expression between pups and adult animals. For the pups samples we used 3 biological replicates and for the adult samples we used 2 biological replicates with 2 technical replicates for each.
Project description:To assess in order to assess potential disparities in gene expression due to developmental differences we performed a comparison between hippocampus and heart tissues from rat and mouse pup (one week old) and adult (10 week old) animals.
Project description:We isolated mRNA from adult mouse (C57BL/6J background) hearts and performed mRNA micro-array analysis to compare gene expression profiles between control and Rhau-deletion mice (inducible deletion by tamoxifen).