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ABSTRACT: Mycobacterium tuberculosis Beijing genotype strains from Omsk

PROVIDER: PRJNA489691 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7796665_1.fastq.gz	Fastqsanger.gz
	SRR7796665_2.fastq.gz	Fastqsanger.gz
	SRR7796666_1.fastq.gz	Fastqsanger.gz
	SRR7796666_2.fastq.gz	Fastqsanger.gz
	SRR7796667_1.fastq.gz	Fastqsanger.gz

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Project description:Mycobacterium tuberculosis (MTB) Beijing genotype is associated with high virulence and drug resistance worldwide. In Colombia, the Beijing genotype circulates since 1997 predominantly on the pacific coast, being the Beijing-Like SIT-190 more prevalent. This genotype conforms to a drug-resistant cluster and shows a fatal outcome in patients. To better understand virulence determinants, we performed a transcriptomic analysis with a Beijing-Like SIT-190 isolate (BL-323), and Beijing-Classic SIT-1 isolate (BC-391) in progressive tuberculosis (TB) murine model. RNA was extracted from mice lungs on days 3, 14, 28, and 60. On average, 0.6% of the total reads mapped against MTB genomes and of those, 90% against coding genes. The strains were independently associated as determined by hierarchical cluster and multidimensional scaling analysis. Gene ontology showed that in strain BL-323 enriched functions were related to host immune response and hypoxia, while proteolysis and protein folding were enriched in the BC-391 strain. Altogether, our results suggested a differential transcriptional program when evaluating these two closely related strains. The data presented here could potentially impact the control of this emerging, highly virulent and drug resistance genotype.

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Project description:Mycobacterium tuberculosis Beijing genotype from Buryatia

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