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Gene expression profiling from high-fat diet (HFD)-treated and regular diet (RD)-treated lung cancer

ABSTRACT: Gene expression profiling from high-fat diet (HFD)-treated and regular diet (RD)-treated lung cancer

PROVIDER: PRJNA489856 | ENA |

REPOSITORIES: ENA

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Gene expression profiling from high-fat diet (HFD)-treated and regular diet (RD)-treated lung cancer

Project description:We utilized inducible transgenic mouse with spontaneous lung cancer formation driven by mutant EGFR (by Doxycycline induction) for experiments. Mice fed with regular diet (RD) or high-fat diet (HFD) were induced lung cancer followed by tumor burden evaluation. Lung tissues were harvested for whole-genome transcriptomic, gene enrichment analysis, and cytokine array for potential signatures identification.Gene set enrichment analysis showed the whole-genome transcriptome in HFD vs. RD treated lung cancer was enriched in immune responses and cytokine stimulus.

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Expression data from adult Drosophila females [normoxia]

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Expression data from adult Drosophila females [normoxia and IH]

Project description:High-fat diet (HFD) in normoxia causes a worsened phenotype in adult female flies compared to regular diet (RD). Intermittent hypoxia (IH) causes an opposite phenotype both when flies are on RD in IH compared to normoxia and even more dramatically when on HFD in IH compared to HFD in normoxia. We used microarrays to examine the transcriptional changes occurring both on a HFD compared to RD in normoxia, and when IH is introduced.

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Global chromatin accessibility using an Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) reveals epigenomic reprogramming of Adipose tissue macrophages toward proinflammatory and proangiogenic phenotypes in formerly obese mice.

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