Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Proline 152 mutation in p53 abolishes cognate DNA binding, induces gain of function tumorigenesis

ABSTRACT: Proline 152 mutation in p53 abolishes cognate DNA binding, induces gain of function tumorigenesis

PROVIDER: PRJNA489860 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7806404_1.fastq.gz	Fastqsanger.gz
	SRR7806404_2.fastq.gz	Fastqsanger.gz
	SRR7806405_1.fastq.gz	Fastqsanger.gz
	SRR7806405_2.fastq.gz	Fastqsanger.gz
	SRR7806406_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Proline 152 mutation in p53 abolishes cognate DNA binding, induces gain of function tumorigenesis

Project description:We have identified a relatively rare mutation in p53 in an Indian oral cancer patient sample at the fade end of its DNA binding domain [P152L]. Although P152L p53 DBD potentially binds to DNA, the full length protein is completely devoid of cognate site DNA binding ability. Also the mutant protein can efficiently tetramerize. Significantly, this mutant was found to induce cell mobility and proliferation with greater tumorigenic potential in nude mice, the mechanistic details of which is also investigated upon. These data establish P152L as a new gain of function p53 mutation

2019-08-02 | GSE119654 | GEO

Sapientia aquatica strain:SA-152 | isolate:SA-152

Project description:Sapientia aquatica strain:SA-152 | isolate:SA-152 Genome sequencing and assembly

| PRJNA526854 | ENA

Bradyrhizobium ottawaense strain:USDA 152 | isolate:USDA 152

Project description:Bradyrhizobium ottawaense USDA 152 genome sequencing

| PRJNA1115783 | ENA

Paenibacillus sp. M-152

Project description:Paenibacillus sp. M-152 Genome sequencing

| PRJNA505111 | ENA

Prostate cancer-derived small extracellular vesicles promote osteoclastogenesis and cancer-induced osteolysis via miR-152-3p delivery

Project description:Extracellular vesicles (EVs) play critical roles in regulating bone metastatic microenvironment through mediating intercellular communications. Here, we report a direct regulatory mode between tumor cells and osteoclasts in osteolytic metastasis of prostate cancer via vesicular miRNAs transfer. Combined analysis of miRNAs profiles both in tumor-derived small EVs (sEVs) and osteoclasts identified miR-152-3p as a potential osteolytic molecules. Further in vitro experiments showed that sEVs were enriched in miR-152-3p, which targets osteoclastogenic regulator MAFB. Blocking miR-152-3p in sEVs upregulated the expression of MAFB and impaired osteoclastogenesis in recipient osteoclasts. In vivo xenograft mouse model found that blocking of miR-152-3p in sEVs significantly rescued the loss of trabecular architecture, while systemic inhibition of miR-152-3p using antagomiR-152-3p reduced the osteolytic lesions of cortical bone while remaining the basic trabecular architecture. Together, our findings suggest that miR-152-3p carried by prostate cancer-derived sEVs deliver osteolytic signals from tumor cells to osteoclasts, facilitating osteolytic progression in bone metastasis.

2021-02-24 | GSE161419 | GEO

Populus trichocarpa strain:BESC-152

Project description:Populus trichocarpa strain:BESC-152 Genome sequencing

| PRJNA256772 | ENA

Panicum virgatum cultivar:SPR-152

Project description:Panicum virgatum SPR-152 Exome Capture exome

| PRJNA408903 | ENA

Panicum virgatum cultivar:AP13xWBC3xDAC6xVS16 - 152

Project description:Panicum virgatum AP13xWBC3xDAC6xVS16 - 152 - Mapping Population genome sequencing

| PRJNA363265 | ENA

Effect of L-Proline on mouse embryonic stem cells (ESCs)

Project description:We found that the non-essential amino acid L-Proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells. This embryonic stem cell-to-mesenchymal-like transition (esMT) is accompanied by a genome-wide remodeling of the transcriptome We used microarrays to elucidate whether a diverse transcriptional program is the basis of the morphological and motility differences between ESCs and L- Proline treated ESCs (PiCs) Total RNA was extracted from Control (ESCs) and L-Proline treated mouse embryonic stem cells (PiCs) and hybridized on Affimetrix microarrays.

2013-09-05 | E-GEOD-50603 | biostudies-arrayexpress

Roseivirga ehrenbergii strain:SW-152

Project description:Roseivirga ehrenbergii strain:SW-152 Genome sequencing and assembly

| PRJNA309617 | ENA