Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene regulation of PHF6 in mouse developing cortex

ABSTRACT: Gene regulation of PHF6 in mouse developing cortex

PROVIDER: PRJNA490879 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7829930.fastq.gz	Fastqsanger.gz
	SRR7829940.fastq.gz	Fastqsanger.gz
	SRR7829931.fastq.gz	Fastqsanger.gz
	SRR7829941.fastq.gz	Fastqsanger.gz
	SRR7829932.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Gene regulation of PHF6 in mouse developing cortex

Project description:we performed RNAseq between WT/KO and WT/C99F to understand the function of PHF6 in gene regulation

2018-10-30 | GSE119973 | GEO

Gene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq

Project description:This study assessed the impact of germline Phf6-deletion on gene expression in the E15.5 mouse cortex and the impact of Nestin-cre mediated Phf6-deletion on gene expression in cultured E16.5 mouse cortical neurons

2024-09-23 | GSE275729 | GEO

Role of Fgf10 signalling in regulation of gene expression in developing mouse cortex

Project description:Role of Fgf10 signalling in regulation of gene expression in developing mouse cortex

| PRJEB34175 | ENA

Gene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq

Project description:Gene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq

| PRJNA1152848 | ENA

RNA binding by Exosc10 in the developing mouse cortex

Project description:RNA binding by Exosc10 in the developing mouse cortex

| PRJNA689478 | ENA

Transcriptional reprogramming of neural stem cells by a PHF6/EphR signalling pathway [ChIP-Seq]

Project description:The plant homeodomain zinc finger protein,PHF6, is a transcriptional regulator, with its germline mutations causing the X-linked intellectual disability (XLID), Börjeson-Forssman-Lehmann syndrome (BFLS).The precise mechanisms by whichPHF6regulates transcription and how its mutant forms lead to XLID remain poorly characterized. Here, we show genome-wide binding of PHF6 in the developing cortex, most of which overlap (CA)n-microsatellite repeats near genes involved in central nervous system development and neurogenesis. Mice harbouring BFLS patient mutations exhibit defects in neurogenesis and altered neural stem cell fate. Mechanistically, we find that PHF6 regulatesa panel of Ephrin receptors (EphRs)and that PHF6regulation ofEphRis impaired in BFLS mice and ina conditionalPhf6knock-out mouse model. We report that mice harboring BFLS mutations exhibit an increase in embryonic neural stem cell (eNSC) self-renewal, a significant attenuation of newly born neurons, and thatEphRknockdown phenocopies the PHF6 loss-of-function defects in altering eNSC fate. Our results suggest that alterations in eNSC fate specification via a PHF6/EphRtranscriptional pathway leads to impaired neurogenesis in BFLS

2024-02-07 | GSE247836 | GEO

Transcriptional reprogramming of neural stem cells by a PHF6/EphR signalling pathway [RNA-seq]

2024-02-07 | GSE247837 | GEO

RNA sequencing of isogenic Phf6 wild type and Phf6 knockout mouse T-ALL cells

Project description:Loss-of-function mutations Phf6 occur frequently in both adult and pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL). Although Phf6 is widely expressed, little is known about its proposed function as epigenetic regulator and tumor suppressor. To address the role of Phf6 in the leukemia development, here we analyze by RNAseq the gene expression profiles of isogenic Phf6 wild type and Phf6 knockout leukemia cells transformed by overexpression of an oncogenic mutant form of the NOTCH1 receptor.

2019-07-31 | GSE117165 | GEO

Developing mouse embryo

Project description:Developing mouse embryo

| PRJNA888039 | ENA

Transcriptomic changes in ER-HOXB8 mouse cell line on Phf6 knockout

Project description:PHF6 is a transcriptional regulator mutated in 3-5% of acute myeloid leukemia. To understand the effect of loss and clinical mutation of PHF6 on the transcriptome of myeloid cells we generated multiple wildtype and Phf6 knockout clones. We observed that loss of PHF6 upregulated genes related to stemness and downregulates genes related to myeloid differentiation.

2024-11-15 | GSE281625 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data