Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ARID1A regulates condensin II distribution and chromosomal partition [RNA-seq]

ABSTRACT: ARID1A regulates condensin II distribution and chromosomal partition [RNA-seq]

PROVIDER: PRJNA491603 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7853980.fastq.gz	Fastqsanger.gz
	SRR7853981.fastq.gz	Fastqsanger.gz
	SRR7853982.fastq.gz	Fastqsanger.gz
	SRR7853983.fastq.gz	Fastqsanger.gz
	SRR7853976.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

ARID1A regulates condensin II distribution and chromosomal partition

Project description:ARID1A regulates condensin II distribution and chromosomal partition

| PRJNA491495 | ENA

ARID1A regulates condensin II distribution and chromosomal partition [HiC]

Project description:ARID1A regulates condensin II distribution and chromosomal partition [HiC]

| PRJNA491601 | ENA

ARID1A regulates condensin II distribution and chromosomal partition [ChIP-seq]

Project description:ARID1A regulates condensin II distribution and chromosomal partition [ChIP-seq]

| PRJNA491602 | ENA

ARID1A regulates condensin II distribution and chromosomal partition [HiC]

Project description:ARID1A, a subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, influences gene accessibility. However, the role of ARID1A in spatial genomic organization and chromosomal interaction remains elusive. We showed that the SWI/SNF complex interacts with condensin II and they show significant overlapping distributions in enhancers. ARID1A inactivation drives redistribution of condensin II preferentially at enhancers without affecting the interaction between the SWI/SNF and condensing II complexes. ARID1A and condensin II contribute to transcriptionally inactive B compartments, while ARID1A weakens the borders of topologically associated domains. ARID1A inactivation decreases the frequency of genomic interactions over distance, but increases the intermixing of interphase small chromosomes, which was validated by three dimensional chromosome painting. These results demonstrated ARID1A spatially partitions genome and chromosomes.

2019-05-21 | GSE120059 | GEO

ARID1A regulates condensin II distribution and chromosomal partition [ChIP-seq]

2019-05-21 | GSE120058 | GEO

ARID1A regulates condensin II distribution and chromosomal partition [RNA-seq]

2019-05-21 | GSE120057 | GEO

ARID1A regulates condensin II distribution and chromosomal partition

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-05-21 | GSE120060 | GEO

Genome-wide distribution of the three condensin complexes in C. elegans

Project description:Condensins are multi-subunit protein complexes that regulate chromosome structure throughout cell-cycle. Metazoans contain two types of condensin complexes (I and II) with essential and distinct functions. In C. elegans a third type of condensin (IDC) functions as part of the X chromosome dosage compensation complex1,2. We mapped genome-wide binding sites of the three condensin types in C. elegans embryos. Characteristics of condensin binding are similar between condensin types. ChIP-seq profiles of C. elegans subunits of the three condensins in 3-6 replicates from mixed stage embryos, controls are included, and RNA-Seq profiles of C. elegans in 5 replicates from mixed staged embryos. Additionally, ChIP-seq profiles of the condensin II subunit KLE-2 in 6 replicates from L3 with controls, and RNA-Seq profiles of KLE-2 mutants in 3 replicates each from L3.

2013-09-16 | E-GEOD-45678 | biostudies-arrayexpress

High Multiplex Translocation Sequencing Reveals the Versatile Role of Condensin II in Chromosomal Translocations

Project description:Chromosomal translocations play pivotal roles in various physiological and pathological processes, such as immunoglobulin production and tumor progression; however, the infrequency of chromosomal translocation events has impeded the exploration of the underlying mechanisms. To tackle this challenge, we devised a strategy to report and enrich cells with translocations in vitro, in conjunction with a novel method termed High Multiplex Translocation Sequencing (HMTS), to capture genome-wide translocations from multiple bait regions simultaneously. Analysis of HMTS data unveiled a preference for translocations to occur at Topologically Associating Domain (TAD) boundaries, and experimental disruption of the TAD boundary indeed led to a reduction in translocation frequency, exemplified by translocations involving ERG. Knockdown of Cohesin or condensin II was observed distinct roles in translocations. Cohesin deficiency promoted long-distance translocations, while condensin II deficiency promoted short distance translocation, inside TAD, and decreased intra-chromatin long-distance translocation, particularly at TAD boundaries. For inter-chromatin, although condensin II deficiency also decreased the translocation at TAD boundaries, and highly transcription regions while paradoxically slightly increased inter-chromatin translocation ratio, suggesting that condensin II physiologically mediated inter-chromatin interaction at TAD boundary regions but simultaneously restricted interaction from other regions, such as centromere. Our new translocation sequencing method revealed the versatile role of condensin II in controlling intra-chromatin short-distance, long-distance, and inter-chromosome translocations.

2024-05-31 | GSE268339 | GEO

Genome-wide distribution of the three condensin complexes in C. elegans

2013-09-16 | GSE45678 | GEO