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A Population of Navigator Neurons is Essential for Olfactory Map Formation during Critical Period

ABSTRACT: A Population of Navigator Neurons is Essential for Olfactory Map Formation during Critical Period

PROVIDER: PRJNA491936 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7883240.fastq.gz	Fastqsanger.gz
	SRR7883241.fastq.gz	Fastqsanger.gz
	SRR7883242.fastq.gz	Fastqsanger.gz
	SRR7883243.fastq.gz	Fastqsanger.gz
	SRR7883244.fastq.gz	Fastqsanger.gz

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A Population of Navigator Neurons is Essential for Olfactory Map Formation during Critical Period

Project description:In the developing brain, heightened plasticity during the critical period enables the proper formation of neural circuits. Here we identify the “navigator” neurons, a group of perinatally born olfactory sensory neurons, as playing an essential role in establishing the olfactory map during the critical period. The navigator axons project circuitously in the olfactory bulb and traverse multiple glomeruli before terminating in perspective glomeruli. These neurons undergo a phase of exuberant axon growth and exhibit a shortened lifespan. Single cell transcriptome analyses reveal distinct molecular signatures for the navigators. Extending their lifespan prolongs the period of exuberant growth and perturbs axon convergence. Conversely, genetic ablation experiment indicates that, despite postnatal neurogenesis, only the navigators are endowed with the ability to establish a convergent map. The presence and the proper removal of the navigator neurons are both required to establish tight axon convergence into the glomeruli.

2018-10-03 | GSE120199 | GEO

A Population of Navigator Neurons Is Essential for Olfactory Map Formation during the Critical Period.

Project description:In the developing brain, heightened plasticity during the critical period enables the proper formation of neural circuits. Here, we identify the "navigator" neurons, a group of perinatally born olfactory sensory neurons, as playing an essential role in establishing the olfactory map during the critical period. The navigator axons project circuitously in the olfactory bulb and traverse multiple glomeruli before terminating in perspective glomeruli. These neurons undergo a phase of exuberant axon growth and exhibit a shortened lifespan. Single-cell transcriptome analyses reveal distinct molecular signatures for the navigators. Extending their lifespan prolongs the period of exuberant growth and perturbs axon convergence. Conversely, a genetic ablation experiment indicates that, despite postnatal neurogenesis, only the navigators are endowed with the ability to establish a convergent map. The presence and the proper removal of the navigator neurons are both required to establish tight axon convergence into the glomeruli.

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Acquisition of Innate Odor Preference Depends on Spontaneous and Experiential Activities During Critical Period

Project description:Animals possess inborn ability to recognize certain odors to avoid predators, seek food and find mates. Innate odor preference has been thought to be genetically hardwired. Here we report that acquisition of innate odor recognition requires spontaneous neural activity and is influenced by sensory experience during early postnatal development. Genetic silencing of mouse olfactory sensory neurons during the critical period has little impact on odor sensitivity, discrimination and recognition later in life. However, it abolishes innate odor preference and alters the patterns of activation in brain centers. Moreover, exposure to an aversive odor during the critical period abolishes aversion in adulthood in an odor specific manner. The loss of innate aversion is associated with broadened projection of OSNs. Thus, a delicate balance of neural activity is required during critical period in establishing innate odor preference and ectopic projection is a convergent mechanism to alter innate odor valence

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Psychedelics Reopen the Social Reward Learning Critical Period

Project description:Psychedelics Reopen the Social Reward Learning Critical Period

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Project description:A Population of Navigator Neurons is Essential for Olfactory Map Formation during Critical Period

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RNA-seq of fluorescence activated cell sorting purified mature olfactory sensory neurons and progenitor cells

Project description:This experiment studies the gene expression in the mature olfactory sensory neurons and the intermidiate neuronal progenitors in the olfactory epithelia during the critical period. Mature olfactory sensory neurons from OMP-GFP mice and intermediate neuronal progenitors in the olfactory epithelia from Neurog1-GFP mice were FACS purified. PolyA RNA profiles at P2, P3, P7, P9, and P16 were generated by RNA-Seq.

2022-08-29 | GSE147460 | GEO

Time series RNA-Seq of the olfactory epithelia of the mouse

Project description:A series of RNA-Seq experiment were conducted to study the transcriptome changes of olfactory sensory neurons during the critical period. We conducted RNA-seq of the olfactory epithelia at P0, P3, P7, P14, and P21 to identify the gene expression changes in the olfactory epithelia. We also performed RNA-Seq experiment of the olfactory epithelia from Kir2.1 transgenic mice at the same time points to understand the effect of neural activity deprivation on the transcriptome.

2022-08-29 | GSE147459 | GEO

Hordeum vulgare cultivar:Navigator

Project description:Hordeum vulgare cultivar:Navigator Raw sequence reads

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Psychedelics Reopen the Social Reward Learning Critical Period

Project description:Psychedelics are a broad class of drugs defined by their ability to induce an altered state of consciousness. These drugs have been used for millennia in both spiritual and medicinal contexts, and a number of recent clinical successes have spurred a renewed interest in developing psychedelic therapies. Nevertheless, a unifying mechanism that can account for these shared phenomenological and therapeutic properties remains unknown. Here we demonstrate in mice that the ability to reopen the social reward learning critical period is a shared property across psychedelics. Interestingly, the time course of critical period reopening is proportional to the duration of acute subjective effects reported in humans. Furthermore, the ability to reinstate social reward learning in adulthood is paralleled by metaplastic restoration of oxytocin mediated long-term depression (OT-LTD) in the Nucleus Accumbens (NAc). Finally, identification of differentially expressed genes in the ‘open state’ versus ‘closed state’, provides evidence that reorganization of the extracellular matrix (ECM) is a common downstream mechanism underlying psychedelic mediated critical period reopening. Together these results have significant implications for the implementation of psychedelics in clinical practice, as well as the design of novel compounds for the treatment of neuropsychiatric disease.

2023-06-14 | GSE230679 | GEO

Hordeum vulgare cultivar:Navigator

Project description:Hordeum vulgare cultivar:Navigator Transcriptome or Gene expression

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