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ABSTRACT: Echinocandin microevolution causes resistance in Candida parapsilosis

PROVIDER: PRJNA493002 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7898455_1.fastq.gz	Fastqsanger.gz
	SRR7898455_2.fastq.gz	Fastqsanger.gz
	SRR7898456_1.fastq.gz	Fastqsanger.gz
	SRR7898456_2.fastq.gz	Fastqsanger.gz
	SRR7898457_1.fastq.gz	Fastqsanger.gz

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Project description:Echinocandin resistance in Candida glabrata

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Transcriptional response of an azole-resistant Candida parapsilosis isolate.

Project description:This SuperSeries is composed of the following subset Series: GSE27405: Transcriptional response of an azole-resistant Candida parapsilosis isolate [fluconazole]. GSE27407: Transcriptional response of an azole-resistant Candida parapsilosis isolate [posaconazole]. GSE27408: Transcriptional response of an azole-resistant Candida parapsilosis isolate [voriconazole]. Refer to individual Series

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Transcriptional landscape of the pathogenic yeast Candida parapsilosis

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Comprehensive analysis of human keratinocyte and opportunistic pathogenic Candida interactions

Project description:In recent years, microbiome studies revealed that Candida species are common colonisers of the human skin. The distribution of species however varies greatly. Although C. parapsilosis is more likely to resemble skin commensals, opinions are divided, and discrepancies are present regarding C. albicans, that is also often associated with cutaneous candidiasis. Therefore, we aimed to thoroughly assess the nature of skin epithelial cell - Candida interactions. To study species-specific host reponses, we examined phagocytosis, cytokine and metabolic responses in different keratinocytes (HaCaT, HPV-KER) along with host cell damage following fungal stimuli. These results suggest that C. albicans triggers an enhanced antifungal response, thus does not closely resembe skin commensals, like C. parapsilosis. Furthermore, HPV-KER might serve as a more applicable tool for studying keratinocyte antifungal responses. To rigorously examine yeast-keratinocyte interactions, we applied two distinct isolates of both C. albicans (SC5314, WO-1) and C. parapsilosis (GA1, CLIB214). Comparison of the two fungi’s virulence revealed that while C. albicans effectively adheres to human keratinocytes and causes subsequent damage, C. parapsilosis is unable to establish lasting physical contact and causes less harm. In terms of keratinocyte response, both cell lines showed significantly enhanced cellular (% phagocytosis), humoral (IL-6, IL-8) and metabolic responses (2-ketoglutaric acid, citric acid, threorine, hypotaurine) to C. albicans strains, while those towards C. parapsilosis remained relatively low or similar to the control condition. Under certain conditions strain preference was also detected. Of the two cell lines, HPV-KER was more sensitive, as besides interspecies differences, intraspecies differences were also measurable.

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Centromere locations and structure in Candida parapsilosis.

Project description:Investigation of centromeres in the pathogenic yeast Candida parapsilosis, shows that the location of two centromeres are polymorphic within this species. The centromeres consist of large inverted repeats (IRs), surrounding unique sequences. New (neo) centromeres have emerged in one C. parapsilosis isolate even though the original CEN location is undamaged. The neocentromeres do not contain IRs, and have no obvious sequence features.

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Project description:Whole genome microarrays were used to generate the transcriptional profile of Candida parapsilosis in low iron conditions

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