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Salmonella enterica strain:serovar Typhi and Paratyphi A

ABSTRACT: Salmonella enterica strain:serovar Typhi and Paratyphi A Raw sequence reads

PROVIDER: PRJNA493305 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8117560_1.fastq.gz	Fastqsanger.gz
	SRR8117560_2.fastq.gz	Fastqsanger.gz
	SRR8117570_1.fastq.gz	Fastqsanger.gz
	SRR8117570_2.fastq.gz	Fastqsanger.gz
	SRR8117580_1.fastq.gz	Fastqsanger.gz

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Project description:Infection with Salmonella enterica serovar Typhi in humans causes the systemic, life-threatening disease typhoid fever. In the laboratory, typhoid fever can be modeled through the inoculation of susceptible mice with Salmonella enterica serovar Typhimurium. The ensuing disease is characterized by systemic dissemination and colonization of many organs, including the liver, spleen and gallbladder. Using this murine model, we previously characterized the interactions between Salmonella Typhimurium and host cells in the gallbladder and showed that this pathogen can successfully invade gallbladder epithelial cells and proliferate. Additionally, we showed that Salmonella Typhimurium can use bile phospholipids to grow at high rates. These abilities are likely important for quick colonization of the gallbladder during typhoid fever and further pathogen dissemination through fecal shedding. To further characterize the interactions between Salmonella and the gallbladder environment we compared the transcriptome of Salmonella cultures grown in LB or physiological murine bile. Our data showed that many genes involved in bacterial central metabolism are affected by bile, with the citric acid cycle being repressed and alternative respiratory systems being activated. Additionally, our study revealed a new aspect of Salmonella interactions with bile through the identification of phoP as a bile-responsive gene. Repression of phoP expression does not involve PhoPQ sensing of a bile component. Due to its critical role in Salmonella virulence, further studies in this area will likely reveal aspects of the interaction between Salmonella and bile that are relevant to disease.

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