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Systems biology analysis of the effect and mechanism of Qi Jing Sheng Bai granule on leucopenia in mice

ABSTRACT: Systems biology analysis of the effect and mechanism of Qi Jing Sheng Bai granule on leucopenia in mice

PROVIDER: PRJNA494175 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7947050_1.fastq.gz	Fastqsanger.gz
	SRR7947050_2.fastq.gz	Fastqsanger.gz
	SRR7947060_1.fastq.gz	Fastqsanger.gz
	SRR7947060_2.fastq.gz	Fastqsanger.gz
	SRR7947051_1.fastq.gz	Fastqsanger.gz

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Systems biology analysis of the effect and mechanism of Qi Jing Sheng Bai granule on leucopenia in mice

Project description:Qi-Jing-Sheng-Bai granule (QJSB) is a new developed traditional Chinese medicine (TCM) formula. In clinical, it has been used for the treatment of leucopenia. However, the therapeutic mechanism needs further solid investigation. In present study, we first tested the effect of QJSB on leucopenia mice induced by cyclophosphamide. QJSB was administered to leucopenia mice for 8 days. Our experiments showed that QJSB significantly increased the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Meanwhile it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. It also reversed the serum cytokines IL-6 and G-CSF disorders. Then, based on the data of transcripts derived from the bone marrow and metabonomic data from plasma, we integrated transcriptomics, network pharmacology and metabolomics technologies to investigate the mode of action of QJSB. We found that QJSB regulates a series of biological processes such as hematopoietic cell lineage, homeostasis of number of cells, lymphocyte differentiation, metabolic processes (including lipid, amino acid and nucleotide metabolism), B cell receptor signaling pathway, T cell activation, NOD-like receptor signaling pathway. In conclusion, QJSB exerts protective effect against leucopenia in mice probably through accelerating cell proliferation and differentiation, regulating metabolism response pathways and modulating immunologic function at system level. The multi-omics approach might achieve a complementary and verified view for the comprehensive evaluation of therapeutic effects and complex mechanisms of QJSB.

2018-10-20 | GSE120707 | GEO

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice.

Project description:Qi-Jing-Sheng-Bai granule (QJSB) is a newly developed traditional Chinese medicine (TCM) formula. Clinically, it has been used for the treatment of leucopenia. However, its pharmacological mechanism needs more investigation. In this study, we firstly tested the effects of QJSB on leucopenia using mice induced by cyclophosphamide. Our results suggested that QJSB significantly raised the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Additionally, it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. Furthermore, it reversed the serum cytokines IL-6 and G-CSF disorders. Then, using transcriptomics datasets and metabonomic datasets, we integrated transcriptomics-based network pharmacology and metabolomics technologies to investigate the mechanism of action of QJSB. We found that QJSB regulated a series of biological processes such as hematopoietic cell lineage, homeostasis of number of cells, lymphocyte differentiation, metabolic processes (including lipid, amino acid, and nucleotide metabolism), B cell receptor signaling pathway, T cell activation and NOD-like receptor signaling pathway. In a summary, QJSB has protective effects to leucopenia in mice probably through accelerating cell proliferation and differentiation, regulating metabolism response pathways and modulating immunologic function at a system level.

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