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Expression data of lamina propria macrophages from LysMCre and LysMCre Arntfl/fl mice with DSS-induced acute colitis

ABSTRACT: Expression data of lamina propria macrophages from LysMCre and LysMCre Arntfl/fl mice with DSS-induced acute colitis

PROVIDER: PRJNA495506 | ENA |

REPOSITORIES: ENA

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Expression data of lamina propria macrophages from LysMCre and LysMCre;Arntfl/fl mice with DSS-induced acute colitis

Project description:Mice with myeloid ARNT deficiency (LysMCre;Arntfl/fl mice) exhibit defective resolution of DSS-induced acute colitis compared to LysMCre mice. This microarray is carried out to compare the phenotype of lamina propria macrophages from the two cohorts, and to identify factors that are disrupted by myeloid ARNT deficiency and can potentially contribute to the defective resolution of acute colitis.

2018-11-12 | GSE121078 | GEO

The effects of Ring1A on gene expression profiles of lamina propria immune cells in DSS colitis at single cell level

Project description:immune cells in intestinal lamina propria play important roles in pathogenesis of DSS colitis. Here, we used single cell RNA sequencing (scRNA-seq) to reveale the intestinal immune landscape of DSS colitis and study the effects of Ring1A on intestinal immune cells.

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Gene expression patterns in caecal lamina propria mononuclear cells and epithelial cells following preventive administration of T. suis ova in a rabbit model of DSS colitis

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Expression profiles of CD45+ cells in colon lamina propria from macrophage-specific E4BP4 transgenic mouse

Project description:Purpose: The goals of this study are to confirm the hypothesis that E4BP4 regulates colon specific anti-inflammatory macrophage. Methods: We generated transgenic mice (TG) with macrophage-specific E4BP4 overexpression. CD45+ cells in colon lamina propria were isolated at Zeitgeber Time (ZT) 0 from TG mice and WT littermates during the recovery period of dextran sulfate sodium (DSS)-induced colitis, and total RNA was extracted. CD45+ cells in colon lamina propria RNA profiles were generated by deep sequencing for two groups with one mouse sample each. Results: There were significant differences between TG and WT mice. Conclusions: E4BP4 increased the number of M2 macrophage population and upregulated anti-inflammatory genes.

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miRNAs expressed in murine CD4+ T cells of splenocyte and lamina propria lymphocytes

Project description:The levels of some murine mRNAs and proteins are expressed discrepantly between the central immune system and the gut immune system in murine colitis. It was possible that RNA interference would result in some of the discrepancy. Thus, we compared microRNAs that are expressed in CD4+ T cells of spleen (SP) and lamina propria (LP) using Il-10+/- mice (C57BL/6 background) in order to reveal the role of miRNAs in murine colitis. Using 10-week-old female Il-10+/- mice, we investigated the difference in miRNA expressions between CD4+ T cells of spleen and that of lamina propria.

2013-09-01 | E-GEOD-40891 | biostudies-arrayexpress

Single cell analysis of Villin-Cre;Apc min;Lef1 fl/fl (VApcMinL) and ApcMin Epcam- cells and CD45-Epcam- stromal cells from lamina propria at the age of 11 wks.

Project description:Comparison of Villin-Cre;Apc min;Lef1 fl/fl (VApcMinL) and ApcMin Epcam- cells and CD45-Epcam- stromal cells from lamina propria at the age of 11 wks. Two male mice per group was used in the experiment.

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Global genome expression analysis of lamina propria derived WT and Nlrp6-/- Ly6C-hi inflammatory monocytes

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Interleukin 17 B is protective in colitis by regulating colonic mononuclear phagocytes in mice [BMDM]

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