Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of SOX4 in mouse embryonic neural stem cells (NSCs)

ABSTRACT: Role of SOX4 in mouse embryonic neural stem cells (NSCs)

PROVIDER: PRJNA495939 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7969350.fastq.gz	Fastqsanger.gz
	SRR7969343.fastq.gz	Fastqsanger.gz
	SRR7969344.fastq.gz	Fastqsanger.gz
	SRR7969345.fastq.gz	Fastqsanger.gz
	SRR7969346.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 14

Similar Datasets

SOX4 binding profiling in mouse embryonic neural stem cells (NSCs)

Project description:SOX4 binding profiling in mouse embryonic neural stem cells (NSCs)

| PRJNA494850 | ENA

SOX4 binding profiling in mouse embryonic neural stem cells (NSCs)

Project description:By chromatin-immunoprecipitating (ChIP) SOX4 in NSCs we identified genome-wide binding sites for SOX4

2018-10-06 | GSE120894 | GEO

Role of Foxp1 in mouse embryonic neural stem cells (NSCs)

Project description:Role of Foxp1 in mouse embryonic neural stem cells (NSCs)

| PRJNA395036 | ENA

RNA-sequencing of mouse E14.5 embryonic neural stem cells transduced in vitro with a shRNA against Sox4 or a scrambled shRNA

Project description:Through RNA-sequencing we analyzed the differentially expressed genes upon in vitro knockdown of Sox4 in mouse E14.5 embryonic neural stem cells using one shRNA against Sox4

2018-10-12 | GSE121173 | GEO

Palmitoylation of BMPR1a regulates neural stem cell fate

Project description:Neural stem cells (NSCs) generate neurons and glial cells throughout embryonic and postnatal brain development. The role of s-acylation, a reversible post-translational lipid modification of proteins, in regulating fate and activity of NSCs remains largely unknown. We here used an unbiased screening approach to identify proteins that are s-acylated in mouse NSCs.

2019-11-27 | PXD014355 | Pride

Gene expression data from mouse ES cell-derived primitive NSCs and definitive NSCs

Project description:Primitive neural stem cells (NSCs) could be derived from pluripotent mouse embryonic stem (ES) cells, and then differentiate into definitive-type neural stem cells which resemble NSCs obtained from the central nervous system. Hence, primitive NSCs define an early stage of neural induction and provide a model to understand the mechanism that controls initial neural commitment. In this study, we performed microarray assay to analyze the global transcriptional profiles in mouse ES cell-derived primitive and definitive NSCs and to depict the molecular changes during the multi-staged neural differentiation process. Primitive NSCs derived directly from ESCs in Lif (p-NSC_L), primitive NSCs that were sub-cultured in the presence of Lif and FGF (p-NSC_LF), as well as definitive NSCs derived from primitive NSCs in medium containing FGF and EGF, were collected for RNA extraction and hybridization on Affymetrix microarrays. Mouse ESCs and NSCs obtained from mouse embryonic brain (E11.5) were included for controls. For each cell type, we collected two biological replicate samples for microarray analysis.

2014-03-01 | E-GEOD-44608 | biostudies-arrayexpress

Gene expression data from mouse ES cell-derived primitive NSCs and definitive NSCs

2014-03-01 | GSE44608 | GEO

Sox4 links tumor suppression to accelerated aging in mice [Telogen]

Project description:Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone and cardiac development. Aberrantly increased Sox4 expression is linked to malignant transformation and metastasis in several types of human cancer. To study the role of Sox4 in the adult organism, we first generated mice with reduced whole-body Sox4 expression. These mice display a plethora of age-related degenerative disorders and reduced spontaneous cancer incidence, indicating a role for this protein in maintaining adult tissue homeostasis and in tumor growth. To specifically address a role for Sox4 in adult stem cells, we conditionally deleted Sox4 (Sox4cKO) in stratified epithelia. Sox4cKO mice show increased skin stem cell quiescence and DNA damage accumulation, accompanied by resistance to chemical carcinogenesis. These phenotypes correlate with downregulation of cell cycle, DNA repair and skin stem cell genes in the absence of Sox4. Altogether, these findings highlight the importance of Sox4 in adult tissue homeostasis and cancer. Sox4 WT and cKO (conditional KO in skin) skin was collected for microarray hybridization, to study the contribution of Sox4 to skin homeostasis in basal conditions (Telogen)

2015-05-20 | E-GEOD-58154 | biostudies-arrayexpress

Sox4 links tumor suppression to accelerated aging in mice [Hair regeneration]

Project description:Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone and cardiac development. Aberrantly increased Sox4 expression is linked to malignant transformation and metastasis in several types of human cancer. To study the role of Sox4 in the adult organism, we first generated mice with reduced whole-body Sox4 expression. These mice display a plethora of age-related degenerative disorders and reduced spontaneous cancer incidence, indicating a role for this protein in maintaining adult tissue homeostasis and in tumor growth. To specifically address a role for Sox4 in adult stem cells, we conditionally deleted Sox4 (Sox4cKO) in stratified epithelia. Sox4cKO mice show increased skin stem cell quiescence and DNA damage accumulation, accompanied by resistance to chemical carcinogenesis. These phenotypes correlate with downregulation of cell cycle, DNA repair and skin stem cell genes in the absence of Sox4. Altogether, these findings highlight the importance of Sox4 in adult tissue homeostasis and cancer. Sox4 WT and cKO (conditional KO in skin) were plucked and skin was collected for microarray hibridization, to study the contribution of Sox4 to hair regeneration and hair follicle stem cell activation

2015-05-20 | E-GEOD-58153 | biostudies-arrayexpress

Role of SOX4 in mouse embryonic neural stem cells (NSCs)

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-12 | GSE121174 | GEO