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The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis

ABSTRACT: The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis

PROVIDER: PRJNA497264 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8071440_1.fastq.gz	Fastqsanger.gz
	SRR8071440_2.fastq.gz	Fastqsanger.gz
	SRR8071434_1.fastq.gz	Fastqsanger.gz
	SRR8071434_2.fastq.gz	Fastqsanger.gz
	SRR8071435_1.fastq.gz	Fastqsanger.gz

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The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis

Project description:In contrast to mammals, zebrafish has high capacity to regenerate tissue architecture and replace lost neurons after traumatic brain injury. The ependymoglia cells react to the injury and generate new neurons, which migrate to the lessoned site and contribute to the tissue restoration. Understanding molecular and cellular mechanisms underlying this regenerative neurogenesis is the crucial step towards achieving regenerative therapies in the mammalian brain. In order to identify molecular pathways governing this mode of restorative neurogenesis, we analysed changes in the transcriptome of ependymoglia cells and their progeny during regeneration process and identified Aryl hydrocarbon receptor (AhR) to be involved in regulation of ependymoglia differentiation towards post-mitotic neurons. Our in vivo imaging analysis shows that the high AhR signalling promotes direct conversion of newly identified population of ependymoglia into the post-mitotic neurons. In contrast, decrease in AhR signalling promotes ependymoglial proliferation. Interestingly, we observed inactivation of the AhR signalling shortly after the injury and return to the basal levels 7 days post injury (dpi) suggesting the role of AhR in proper timing of the direct conversion of ependymoglia, ensuring the successful repair. Taken together, we identified the role of AhR signalling pathway in regulating differentiation of ependymoglia into the neurons and setting up the proper timing of restorative neurogenesis in zebrafish brain.

2018-10-11 | GSE102400 | GEO

The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis

Project description:We compared transcriptomes of two ependymoglial populations isolated from adult zebrafish telencephalon.

2018-10-18 | GSE121404 | GEO

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Project description:The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis

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The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries

Project description:This SuperSeries is composed of the following subset Series: GSE15857: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney GSE15858: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Liver Refer to individual Series

2010-05-05 | E-GEOD-15859 | biostudies-arrayexpress

Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles

Project description:Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles

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Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles [ATAC-seq]

Project description:Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles [ATAC-seq]

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Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles [PRO-seq]

Project description:Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles [PRO-seq]

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Aryl hydrocarbon receptor dynamically regulates inflammatory and secretory gene pathways in decidual endometrial stromal cells

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Aryl hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

Project description:Aryl hydrocarbon receptor-interacting protein (AIP), a putative positive intermediary in aryl hydrocarbon receptor-mediated signaling, is overexpressed in highly metastatic human KM12SM CRC cells, with high metastatic capacity to liver, and other highly metastatic CRC cells. Meta-analysis and immunohistochemistry were used to assess the relevance of this protein in CRC. Cellular functions and signaling mechanisms mediated by AIP were assessed by gain-of-function experiments and in vitro and in vivo experiments. A significant association of high AIP expression with poor CRC patients’ survival was observed. Gain-of-function and quantitative proteomics experiments demonstrated that AIP increased tumorigenic and metastatic properties of isogenic KM12C (poorly-metastatic) and KM12SM CRC cells. AIP overexpression dysregulated epithelial-to-mesenchymal (EMT) markers and induced several transcription factors and Cadherin-17 activation. The former induced the signaling activation of AKT, SRC, and JNK kinases to increase adhesion, migration and invasion of CRC cells. In vivo, AIP expressing KM12 cells induced tumor growth and liver metastasis. Furthermore, KM12C (poorly-metastatic) cells ectopically expressing AIP became metastatic to liver. Our data reveal new roles for AIP in regulating proteins associated with cancer and metastasis to induce tumorigenic and metastatic properties in colon cancer cells driving liver metastasis.

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Expression data of primary melanocytes from aryl hydrocarbon deficient mice and corresponding wild-type C57BL/6 mice

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2010-09-05 | E-GEOD-19411 | biostudies-arrayexpress

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