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Gene expression in Tbr2 lineage neurons in the murine cerebral cortex

ABSTRACT: Gene expression in Tbr2 lineage neurons in the murine cerebral cortex

PROVIDER: PRJNA497431 | ENA |

REPOSITORIES: ENA

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Gene expression in Tbr2 lineage neurons in the murine cerebral cortex

Project description:During cortical development neurons are generated from basal progenitors (BPs) which specifically express the transcription factor Tbr2. We used fluorescent-activated cell sorting (FACS) to isolate Tbr2-lineage neurons (GFP+) from mice brain at postnatal day 2 (P2) and determined mRNA expression profiles using microarray (Illumina MouseWG-6 v2). Role of transcription factor Tbr2 in neurodevelopment.

2019-10-18 | GSE121470 | GEO

Transcriptome analyses of cortical projection neurons and interneurons via Tbr2(Eomes)-mediated transgenic lineage tracing

Project description:In the cerebral cortex, projection neurons and interneurons work coordinately to establish functional neural networks and to control the balance between excitatory versus inhibitory synaptic activities for normal cortical functions. While the specific mechanisms that control productions of projection neurons and interneurons are beginning to be revealed, a global characterization of the molecular differences between these two groups of neurons is in need for a more comprehensive understanding of their developmental specifications as well as their cortical functions. Previous studies have shown that the majority of cortical projection neurons are produced by radial glial cells (RGCs) through intermediate progenitor cells (IPCs) which can be marked by the expression of transcription factor Tbr2(Eomes). In this study, taking advantage of lineage tracing power of combining Tbr2(Eomes)-GFP and DCX-mRFP transgenic reporter mice, we prospectively separated IPC-derived neurons (IPNs) from non-IPC-derived neurons (non-IPNs) of the embryonic cortex. Molecular characterizations revealed that IPNs and non-IPNs were enriched with projection neurons and interneurons, respectively. Transcriptome analyses documented distinct groups of genes differentially expressed between these two groups of neurons. These data present a useful resource for further investigation of the molecular regulations and functions of projection neurons and interneurons.

2015-08-12 | GSE62042 | GEO

Transcriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices

Project description:The abscence of TBR2 gene in human leads to microcephaly. This condition is mimicked by the specific ablation of the murine gene in developing cerebral cortex. Herein we compared gene expression in control and Tbr2 cKO in E14.5 cerebral cortices. This approach represents a useful tool to identify the molecular mechanisms at the basis of the phenotype. 6 samples, 3x Tbr2 +/+;Foxg1::Cre (control) and 3x Tbr2 fl/fl;Foxg1::Cre

2016-09-08 | E-GEOD-63619 | biostudies-arrayexpress

Gene expression in basal progenitors in the cerebral cortex of Tbr2 conditional knockout mice

Project description:During cortical development neurons are generated from basal progenitors (BPs) which specifically express the transcription factor Tbr2. We used fluorescent-activated cell sorting (FACS) to isolate BPs from Tbr2-conditional knockout mice brain at early (E13) and late (E16) stages of cortical neurogenesis and determined mRNA expression profiles using microarray (Illumina MouseWG-6 v2). Role of transcription factor Tbr2 in basal progenitors during corticogenesis.

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Mouse cerebral cortex neurons proteomics response to West Nile Virus (WNV)

Project description:Proteomics data from mouse cerebral cortex neurons; Treated with wild-type and mutant WNV, and mockulum

2016-01-21 | MSV000079468 | MassIVE

Molecular lineage and spatial distribution of subplate neurons in the human fetal cerebral cortex.

Project description:Subplate neurons (SPNs) are among the firstborn neurons in the human fetal cerebral cortex, and play a critical role in establishing intra- and extracortical connections. In this study, we created spatial landscapes and molecular lineages of SPNs by performing spatial transcriptomics, and revealed precise position information of various cortical cell types including subplate neurons and their high diversity in the human fetal cortex. Through the spatial distribution of subplate neurons, we identified the molecular signatures of subplate neurons that are closer to early-born neurons than late-born neurons. We also analyzed human-specific genes and extracellular matrix genes enriched in subplate neurons, highlighting the potential contributions of subplate neurons to cortical neurogenesis and early structural folding.

2024-12-27 | GSE262082 | GEO

Transcriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices

2016-09-08 | GSE63619 | GEO

Molecular lineage and spatial distribution of subplate neurons in the human fetal cerebral cortex.

Project description:Molecular lineage and spatial distribution of subplate neurons in the human fetal cerebral cortex.

| PRJNA1090142 | ENA

Gene expression in basal progenitors in the cerebral cortex of Tbr2 conditional knockout mice

Project description:Gene expression in basal progenitors in the cerebral cortex of Tbr2 conditional knockout mice

| PRJNA496025 | ENA

RNA-Seq and ChIP-Seq from Tbr2+ and Tbr2- nuclei

Project description:We performed RNA-Seq and H3K9ac ChIP-Seq from Tbr2+ and Tbr2- nuclei sorted by FACS from E16.5 embryonic cortex treated with either vehicle or HDAC inhibitor (TSA).

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